可降解与不可降解涂层雷帕霉素洗脱支架植入后高敏C反应蛋白和白细胞介素6水平变化

目的 观察可降解涂层与不可降解涂层雷帕霉素药物洗脱支架植入后循环与局部高敏C反应蛋白和白细胞介素6水平变化.方法 连续入选118例接受PCI治疗植入1枚支架的不稳定型心绞痛患者,分为不可降解涂层组(n=65)和可降解涂层组(n=53).于术前、术后即刻、48 h、7天及9月时抽取静脉血,术前、术后即刻及术后9月冠状动脉造影随访时以微导管抽取冠状动脉局部血液,测定高敏C反应蛋白和白细胞介素6水平.结果 两组基本临床资料、PCI术情况无明显差异.两组术后即刻支架局部血清白细胞介素6水平较术前显著升高;术后48 h和7天循环高敏C反应蛋白和白细胞介素6水平明显高于术前.两组间比较,PCI术前、术后即刻、48 h、7天和9月时循环及局部高敏C反应蛋白和白细胞介素6水平均无明显差异.结论 可降解涂层与不可降解涂层雷帕霉素洗脱支架对术后循环与局部炎症反应的影响可能相似.

Changes of High Sensitivity C-Reactive Protein and Interleukin-6 Levels After Implantation of Degradable and Non-Degradable Coating with Siromulus Eluting Stents

Aim To observe the effects of degradable coating and non-degradable coating with sirolimus-eluting stents on systemic and local levels of high sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6).Methods Consecutive 118 patients with unstable angina pectoris(UAP)with a stent implanted were involved and divided into non-degradable coating group(n=65)and degradable coating group(n=53).The serum concentrations of hs-CRP and IL-6 were determined before and immediately,at 48 hours,7 days,and 9 months after coronary intervention,and local levels in coronary were determined before and immediately,at 9 months after stent implantation.Results There was no significant difference in clinical and angiographic baseline characteristics and basic serum hs-CRP and IL-6 concentrations between the two groups.The local IL-6 levels increased immediately after stent implation in both group.The circulatory serum hs-CRP and IL-6 levels at 48 hours and 7 days after stenting were significantly higher in both group compared with baseline.When compared between the two groups,there was no significant difference of hs-CRP and IL-6 levels at 48 hours,7 days,and 9 months after stenting both in systemic and in local levels.Conclusion It seemed that degradable coating and non-degradable coating with sirolimus-eluting stents may display similar effects on systemic and local inflammation.