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Metabolic supervision by PPIP5K,an inositol pyrophosphate kinase/phosphatase,controls proliferation of the HCT116 tumor cell line |
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| Authors: | Chunfang Gu Juan Liu Xiaojing Liu Haibo Zhang Ji Luo Huanchen Wang Jason W. Locasale Stephen B. Shears |
| Affiliation: | aSignal Transduction Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709;bDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710;cLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892 |
| Abstract: | |
| Keywords: | inositol pyrophosphates, PPIP5K, nucleotide synthesis, pentose phosphate pathway, serine– glycine– one-carbon metabolism |