茵陈蒿化学成分的分离与鉴定

目的 分离并鉴定茵陈蒿（Artemisia capillaries Thunb.)中的化学成分，以寻找具有活性的化合物，为中药新药研发奠定基础。方法 采用硅胶柱色谱、羟丙基葡聚糖凝胶柱色谱、制备HPLC多种分离方法，对茵陈蒿的水提取物的乙酸乙酯和正丁醇萃取部分进行分离，根据理化性质和波谱学数据鉴定化学结构。结果 分离鉴定了9个已知化合物，分别为7-甲氧基香豆素(1)、对羟基苯乙酮(2)、烟酸(3)、3(R)-癸-4,6,8-三炔-1,3-二醇(4)、3(R)-癸-4,6,8-三炔-1,3-二醇-1-O-β-D-吡喃葡萄糖苷(5)、3(R)-9-癸烯-4,6-二炔-1,3,8-三醇(6)、对羟基苯乙酮吡喃葡萄糖苷 (7)、苯甲醇-β-D-吡喃葡萄糖苷(8)和胸腺嘧啶脱氧核苷(9)。结论 化合物4~7为首次从该属植物中分离得到。

Isolation and identification of chemical constituents from Artemisia capillaries Thunb

Aim To isolate the chemical constituents and to elucidate their structures from Artemisia capilla-ries Thunb.Methods The compounds were isolated by silica gel column,Sephadex LH-20 column chromatography and HPLC techniques.And these compounds were identified by the physico-chemical properties and spectral analysis.Results Nine compounds were obtained and their structures were elucidated as 7-methoxycoumarin(1),4-hydroxyacetophenone(2),nicotinic acid(3),3(R)-deca-4,6,8-triyne-1,3-diol(4),3(R)-deca-4,6,8-triy...