血浆IGF-1水平与糖尿病神经病变关系的研究

目的　了解血浆IGF -1水平与 2型糖尿病神经病变 (DNP)的关系。方法　观察 2型DM患者 115例 ,并依据合并神经病变的严重程度分为 0级DNP组 2 2例 ,1级DNP组 5 6例 ,2级DNP组 2 5例 ,3级DNP组 12例。观察对象分别测定体重指数、FBS、空腹C肽 (CP0 )、餐后 2hC肽 (CP2 )、糖化血红蛋白 (GHbA1C)及IGF -1,并行肌电图检查。血浆IGF -1采用放免法测定 ,各组间差异显著性使用单因素方差分析。结果　血浆IGF -1水平与DNP的严重程度呈显著负相关 (P <0 0 5 ) ;1,2 ,3级DNP组血浆IGF -1水平 分别为 ( 117 48± 40 3 4 ) μm/ml,( 115 .61± 3 5 .48) μg/ml,( 10 0 .87± 2 0 .42 ) μg/ml]显著低于 0级DNP组 ( 14 5 42± 5 7.70 ) μg/ml,分别为P <0 .0 5 ,P <0 .0 5 ,P <0 .0 1] ;而 1,2 ,3级DNP组间血浆IGF -1水平差异无显著性。结论　循环中IGF -1水平降低可能参与了DNP的发生及发展。

Plasma level of IGF-1 in type 2 diabetic patients with nueropathy

Objective　To evaluate the possible relationship between plasma insulin-like growth factor-1 (IGF-1) and diabetic neuropathy (DNP) in type 2 diabetic patients.Methods　Plasma concentrations of IGF-1,FBS,GHbA1C,fast C-peptide and postprandial C-peptide were measured in 115 cases of type 2 diabetes (22 with grade 0 DNP,56 with grade 1 DNP,25 with grade 2 DNP,12 with grade 3 DNP).Muscular electrometry was also performed.Plasma concentrations of IGF-1 were measured by immunoradioassay analysis.Results　Plasma IGF-1 levles inversely correlated with the grades of DNP in type 2 diabetic patients (P＜0.05).Patients with grade 1,2 or 3 of DNP had significant lower plasma IGF-1 concentration ［(117.48±40.34） μg/ml,（115.61±35.48） μg/ml and （100.87±20.42） μg/ml,respectively］ than that of grade 0 (145.42±57.70） μg/ml （P＜0.05,P＜0.05,P＜0.01 respectively）,while plasma IGF-1 concentrations had no significant differences among groups of grade 1,2 or 3.Conclusion　Decreased plasma IGF-1 in type 2 diabetic patients may contribute to the pathogensis of neuropathy.