| 短暂性脑缺血发作与脑缺血耐受研究进展 |
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| 引用本文： | 林晓东.短暂性脑缺血发作与脑缺血耐受研究进展[J].中华脑血管病杂志(电子版),2009,3(2):41-44. |
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| 作者姓名： | 林晓东 |
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| 作者单位： | 河北省秦皇岛市第二医院神经内科,河北省秦皇岛,066600 |
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| 摘 要： | 脑缺血耐受是近年来的研究热点。短暂性脑缺血发作虽然使缺血性卒中危险增加，但同时可诱导神经细胞对再次缺血产生耐受。耐受的机制涉及血管因素、腺苷、兴奋性氨基酸、热休克蛋白、低氧诱导因子-1、促红细胞生成素、KATP通道等。临床观察显示，TIA的持续时间、发作频度、脑梗死间隔时间以及脑梗死体积等均与耐受的发生有关。
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| 关 键 词： | 短暂性脑缺血发作 脑梗死 缺血耐受性 |
The Progress in transient ischemic attack and ischemic tolerance |
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| LIN Xiao-dong.The Progress in transient ischemic attack and ischemic tolerance[J].Chinese Journal of Cerebrovascular Diseases(Electronic Version),2009,3(2):41-44. |
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| Authors: | LIN Xiao-dong |
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| Institution: | LIN Xiao-dong.(Department of Neurology , Qinhuangdao second Hospital, Qinhuangdao 066600, China) |
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| Abstract: | Cerebral ischemic tolerance is a research hotspot in recent years. Transient ischemic attack（TIA） has brought increased risk of ischemic stroke, but at the same time can induce nerve cells to re-ischemic tolerance. Tolerance mechanisms involved in blood vessels, adenosine, excitatory amino acids, heat-shock protein, hypoxic inducible factor -1,erythropoietin, KATP channel and so on. The clinical observation shows that, TIA duration, frequency of TIA, interval of TIA and cerebral infarction volume and so on were related to the occurrence of tolerance. |
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| Keywords: | Transient ischemic attack Cerebral infarction Ischemic tolerance |
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