孕前及孕期母亲被动吸烟与儿童孤独症谱系障碍的关联分析

目的 探讨孕前及孕期母亲被动吸烟暴露与子代孤独症谱系障碍(ASD)发生风险的关联,为ASD的预防提供理论依据.方法 采用病例对照研究,选取2018-2020年广州市妇女儿童医疗中心和康复机构确诊的141名ASD儿童(ASD组)和247名正常健康儿童(对照组)纳入研究,采用调查问卷收集家庭一般情况与烟草被动暴露情况等资料...

Association between maternal passive smoking exposure before/during pregnancy and the risk of autism spectrum disorders in offspring

Objective To explore the association between maternal passive smoking exposure before/during pregnancy and the risk of autism spectrum disorders (ASD) in offspring, so as to provide theoretical reference for the prevention of ASD. Methods A total of 141 children diagnosed with ASD (ASD group) in Guangzhou Women and Children's Medical Center and a rehabilitation organization and 247 healthy children (control group) were enrolled in this case-control study. The questionnaire survey was performed to collect the general characteristics and parental passive smoking exposure information. Univariate and multivariate Logistic regression analysis were used to examine the association between perinatal maternal passive smoking exposure and the risk of ASD in their offspring. Results Maternal passive smoking exposure either before pregnancy (crude OR=6.69,95%CI:2.33 - 19.25) or during pregnancy(crude OR=5.78,95%CI:2.15 - 15.49) had significantly increased the risk of ASD in their offspring. After adjusting the confounders such as children's sex, parity, maternal education, maternal vitamin intake and paternal passive smoking before pregnancy, the trends above remained. After sex matching, the sensitivity analysis showed that maternal tobacco exposure before and during pregnancy still served as a risk factor for offspring's ASD. Conclusion Perinatal maternal passive smoking exposure might be associated with the increasing risk of offspring's ASD.