丁苯酞对急性脑梗死患者NIHSS及血液流变学的影响

目的 探讨丁苯酞治疗急性脑梗死（Acute cerebral infarct）患者神经功能缺损评分（national institute of health stroke scale,NIHSS）及血液流变学影响。方法 选取昆明市第二人民医院神经内科2020年3月至2021年4月医院接收的66例急性脑梗死患者，采用数字随机表法分为研究组和对照组。对照组设为常规治疗，研究组在对照组常规治疗基础上联合丁苯酞进行治疗，并检测对比2组血液流变学、治疗前后2组疗效、神经功能缺损评分以及日常生活能力不良反应。结果 治疗后，研究组总有效率高于对照组，差异有统计学意义（P <0.05）；治疗后，研究组NHISS评分低于对照组，Barthel指数高于对照组，差异有统计学意义（P <0.05）；治疗后，研究组血液流变学指标（全血比黏度、血浆比黏度、红细胞压积、血小板聚集率）均低于对照组，差异有统计学意义（P <0.05）；治疗后，研究组不良反应率与对照组比较，差异无统计学意义（P> 0.05）。结论 采用丁苯酞对急性脑梗死患者进行治疗，其效果较好，患者神经功能缺损情况以及血液流变学...

Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction

  Objective  To investigate the influence of butylphthalide on National Institute of Health stroke Scale （NIHSS） and hemorheology in patients with acute cerebral infarction.   Methods  A total of 66 patients with acute cerebral infarction admitted to the Department of Neurology of Kunming Second People’s Hospital from March 2020 to April 2021 were selected and divided into study group and control group by numerical random table method. The control group received routine treatment, and the research group was treated with butylphthalide on the basis of routine treatment as in the control group. Hemorheology, efficacy of the two groups before and after treatment, neurological deficit score and adverse reactions of daily living ability were detected and compared.   Results   After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant （P < 0.05）. After treatment, the NHISS score of the study group was lower than that of the control group, and the Barthel index was higher than that of the control group, with statistical significance （P < 0.05）. After treatment, the hemorheology indexes （whole blood specific viscosity, plasma specific viscosity, hematocrit and platelet aggregation rate）in the study group were lower than those in the control group, and the differences were statistically significant （P < 0.05）. There was no significant difference in the adverse reaction rate between the study group and the control group （P > 0.05）.  Conclusion  The use of butylphthalide for the treatment of acute cerebral infarction patients is effective, with improvement in patients’ neurological functions and hemorheology indicators. It is safe and worthy of application and promotion.