| 二甲双胍的放疗增敏机制及临床应用前景分析北大核心CSCD |
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| 引用本文： | 熊鑫,范兴文.二甲双胍的放疗增敏机制及临床应用前景分析北大核心CSCD[J].中华放射肿瘤学杂志,2022,31(10):966-970. |
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| 作者姓名： | 熊鑫 范兴文 |
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| 作者单位： | 复旦大学上海医学院,上海 200032;复旦大学附属肿瘤医院放射治疗中心,复旦大学上海医学院肿瘤学系,上海市放射肿瘤学重点实验室,上海 200032 |
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| 摘 要： | 二甲双胍是2型糖尿病的基础用药。越来越多研究显示二甲双胍具有抗肿瘤作用,同时其放射增敏作用也逐渐被发现。二甲双胍可通过改善乏氧、增加活性氧、抑制DNA损伤修复、诱导细胞周期阻滞、调节免疫微环境等机制增加肿瘤细胞的放射敏感性。但近期公布的几项随机对照研究却未证实二甲双胍能增加放化疗疗效。本文梳理了二甲双胍的放疗增敏机制和临床结果,二甲双胍的剂量是未来开展基础和临床研究的重要考量因素。
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| 关 键 词： | 二甲双胍 放射疗法 放疗增敏 |
| 收稿时间： | 2021-04-08 |
Radiosensitization mechanism of metformin and analysis of clinical application prospect |
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| Xiong Xin,Fan Xingwen.Radiosensitization mechanism of metformin and analysis of clinical application prospect[J].Chinese Journal of Radiation Oncology,2022,31(10):966-970. |
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| Authors: | Xiong Xin Fan Xingwen |
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| Institution: | Shanghai Medical College, Fudan University, Shanghai 200032, China;Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai 200032, China |
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| Abstract: | Metformin is the basic drug for type 2 diabetes mellitus. More and more studies have shown that metformin has anti‐tumor effect, and its radiosensitization effect has been gradually found. Metformin can increase the radiosensitivity of tumor cells by improving hypoxia, increasing reactive oxygen species, inhibiting DNA damage repair, inducing cell cycle arrest and regulating immune microenvironment. However, several recently published randomized controlled trials have not confirmed that metformin can increase the efficacy of chemoradiotherapy. In this review, the mechanism and clinical results of metformin radiosensitization were summarized. The dose of metformin will be an important factor for basic and clinical research in the future. |
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| Keywords: | Metformin Radiotherapy Radiosensitization |
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