外周血中性粒细胞/淋巴细胞比值及其与成分输血不良反应的关系

 目的 分析外周血中性粒细胞/淋巴细胞比值(neutrophil to lymphocytes ratio,NLR)及其与成分输血不良反应的关系。方法 选取2015-05至2020-05武警兵团总队医院接受成分输血且发生不良反应69例患者的临床资料,作为发生组;并选取同期接受成分输血且未发生不良反应72例患者的临床资料,作为未发生组。输血前检测并比较两组中性粒细胞、淋巴细胞及NLR,采用回归分析检验输血前NLR对成分输血患者发生不良反应的影响,并绘制ROC曲线预测成分输血不良反应风险的价值。结果 发生组输血前中性粒细胞水平、淋巴细胞及NLR均高于未发生组(P<0.05);回归分析结果显示,输血前NLR过表达是成分输血患者发生不良反应的影响因素(OR＞1,P<0.05);绘制ROC曲线结果显示,输血前NLR预测成分输血患者发生不良反应的曲线下面积(AUC)为0.834,预测价值较理想。结论 成分输血患者治疗期间不良反应的发生风险可能与外周血NLR过表达有关。

Correlations between the neutrophil to lymphocytes ratio in peripheral blood and adverse transfusion reactions during blood component transfusion

Objective To analyze the correlations between the neutrophil to lymphocytes ratio in the peripheral blood of patients with adverse reactions caused by component transfusion and related adverse reactions.Methods The clinical data on 69 patients who had received component transfusion and developed adverse reactions between April 2018 and December 2019 was collected as the occurrence group, while the clinical data on another 72 patients who had received component transfusion without any adverse reactions in the same period served as the non-occurrence group. The levels of neutrophils, lymphocytes and the neutrophil to lymphocytes ratios were detected in both groups before blood transfusion. Regression analysis was used to determine the effect of the neutrophil to lymphocyte ratio before blood transfusion on the incidence of adverse reactions in patients with component blood transfusion, and the ROC curve was drawn to predict the value of risk of adverse reactions of component transfusion.Results The levels of neutrophils, lymphocytes and the neutrophil to lymphocyte ratio before blood transfusion in the occurrence group were higher than those in the non-occurrence group (P<0.05). The results of regression analysis showed that the overexpression of the neutrophil to lymphocytes ratio could influence the incidence of adverse reactions in component transfusion patients (OR>1, P<0.05). The area under the curve (AUC) of adverse reactions in component transfusion patients was 0.834,which was predicted by the neutrophil to lymphocyte ratio before blood transfusion , so the predictability was satisfactory.Conclusions The risk of adverse reactions among component transfusion patients may be related to the overexpression of the neutrophil to lymphocytes ratio in peripheral blood.