| 他克莫司致高血压的机制研究进展 |
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| 引用本文： | 袁帅杰,徐明.他克莫司致高血压的机制研究进展[J].中国医院药学杂志,2022,42(19):2075-2079. |
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| 作者姓名： | 袁帅杰 徐明 |
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| 作者单位： | 中国药科大学基础医学与临床药学学院, 江苏 南京 211100 |
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| 基金项目： | 国家自然科学基金资助项目（编号：81973509） |
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| 摘 要： | 他克莫司作为临床常用的免疫抑制剂，极大地改善了移植患者的预后。但他克莫司存在高血压的不良反应，限制了其应用，然而该不良反应的机制尚未完全明晰。因此，本文综述了他克莫司诱导高血压的机制，以期为临床上选择合适的预防与治疗方案提供参考。
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| 关 键 词： | 钙调磷酸酶抑制剂 他克莫司 高血压 |
| 收稿时间： | 2022-03-31 |
Research advance in the mechanisms of tacrolimus-induced hypertension |
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| YUAN Shuai-jie,XU Ming.Research advance in the mechanisms of tacrolimus-induced hypertension[J].Chinese Journal of Hospital Pharmacy,2022,42(19):2075-2079. |
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| Authors: | YUAN Shuai-jie XU Ming |
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| Institution: | School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Nanjing 211100, China |
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| Abstract: | As a commonly used immunosuppressant, tacrolimus has greatly improved the prognosis of transplant patients. However, tacrolimus has the adverse reaction of hypertension, which limits its application, and the mechanisms of the adverse reaction are not completely clear. Therefore, this paper reviewed the mechanisms of tacrolimus-induced hypertension in order to provide reference for the selection of appropriate prevention and treatment plan in clinic. |
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| Keywords: | calcineurin inhibitors tacrolimus hypertension |
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