3137例体检人群血清GGT水平和血脂指标的相关性研究

  目的  探讨体检人群γ-谷氨酰基转移酶（gamma-glutamyl transferase，GGT）升高与血脂代谢异常的相关性。  方法  选取2020年4月至2021年8月3137例体检者作为研究对象，采集基线资料、GGT和血脂代谢指标。血脂代谢指标分别为总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、高密度脂蛋白（high lipoprotein，HDL）和低密度脂蛋白（low density lipoprotein，LDL）共计4项指标。依据GGT浓度的四分位数进行分组，对血脂四项指标水平进行组间的两两比较；分别分析GGT浓度与血脂4项指标的相关性；比较GGT在不同血脂异常分组间的水平差异；应用二元Logistic回归多因素分析筛选出影响GGT升高的危险因素。  结果   随着GGT浓度的升高，TC、TG和LDL水平及异常率明显上升，HDL水平明显降低且异常率增加，差异均具有统计学意义（P < 0.05）；Spearman相关性分析显示，GGT与TC、TG、LDL浓度水平均呈正相关（r_s = 0.200、0.395、0.186，P < 0.05），而与HDL呈负相关（r_s = -0.144，P < 0.05）；二元Logistic回归多因素分析显示，以中位数或参考值为界定，TG均是影响GGT浓度升高的独立危险因素，OR值分别为2.360（95% CI:2.068～2.695）和1.635（95% CI:1.481～1.805）。  结论  血脂代谢紊乱会导致GGT的异常升高，且升高幅度与血脂代谢异常程度密切相关。伴随有血脂异常的GGT升高可能有助于脂质代谢紊乱相关性疾病的诊断和治疗。

Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population

  Objectives  To explore the relationship between the increase of Gamma-glutamyl transferase （GGT） and dyslipidemia in checkup population.   Methods  3137 subjects were selected from April 2020 to August 2021. The baseline data, GGT, and four serum lipid indexes of total cholesterol （TC）, triglyceride （TG）, high lipoprotein （HDL） and low density lipoprotein （LDL） were collected. First of all, according to the quartile of GGT concentration, the levels of the four indexes of blood lipids were compared; secondly, the correlation between the concentration of GGT and the four indexes of blood lipids was analyzed; again, the differences of GGT levels among different groups of dyslipidemia were compared; finally, the risk factors affecting the increase of GGT were screened out by binary Logistic regression analysis.   Results  With the increase of GGT concentration, the abnormal rate and abnormal level of TC, TG and LDL increased significantly, and the abnormal rate of HDL increased and the abnormal level decreased significantly, and the differences were statistically significant （all P < 0.05）; Spearman correlation analysis showed that GGT was positively correlated with TC, TG and LDL （r = 0.200, 0.395, 0.186, all P < 0.05）, and negatively correlated with HDL （r = -0.144, P < 0.05）; The concentration of GGT increased with the increase of abnormal indexes in the four indexes （all P < 0.05）; The multivariate analysis of binary Logistic regression showed that TG was an independent risk factor for the increase of GGT concentration, regardless of the median or reference value of GGT positive, and the OR values were 2.360 （95%CI: 2.068～2.695） and 1.635 （95%CI: 1.481～1.805）, respectively.   Conclusions  The increase of GGT can be caused by the disorder of blood lipid metabolism, and the degree of increase is closely related to the severity of dyslipidemia. Persistent elevated GGT associated with dyslipidemia may be helpful in the diagnosis and treatment of dyslipidemia-related diseases.