抽动障碍儿童血清锌、铁、铅、铜、镁、钙含量的Meta分析

目的 探究抽动障碍儿童血清微量元素含量与正常健康儿童的差异,为抽动障碍的防治提供参考.方法检索中国知网数据库(CNKI)、重庆维普中文科技期刊数据库(VIP)、万方数据库(Wanfang Data)、临床试验注册中心、Pubmed、Embase、Cochrane Library及Web of Science等数据库,检...

Meta-analysis of serum zinc,iron, lead,copper, magnesium and calcium in children with tic disorder

Objective To explore the difference of serum trace elements between children with tic disorder (TD) and healthy children, in order to provide reference for the prevention and treatment of TD. Methods CNKI,VIP, Wanfang, Clinical Trial Registration Center, Pubmed, Embase, Web of Science and Cochrane Library were searched to retrieve case-control studies where serum levels of zinc, iron, lead, copper, magnesium, calcium and other elements in TD children were tested.Keywords included tic disorder/TD, trace elements, blood lead, blood zinc, blood iron, etc.RevMan 5.3 and Stata 15 were used to conduct Meta-analysis. Results A total of 19 articles in Chinese and English were finally included, with a time span of 15 years.Totally 3 762 TD children and 4 800 healthy children in the control group were included.Meta-analysis results showed that compared with healthy children, TD children had higher serum level of lead (MD=23.75, 95%CI:13.57 - 33.92, P＜0.001), lower serum levels of iron (MD=-62.64, 95%CI:-84.35 - -40.93, P＜0.001) and zinc (MD=-0.87, 95%CI:-1.19 - -0.55, P＜0.001),but no significant difference was found in serum magnesium, calcium and copper(P＞0.05).Logistic regression analysis showed that the abnormality of serum lead, zinc and iron was related to tic disorder. Conclusions Children with TD have higher level of serum lead and lower level of serum zinc and iron.And the abnormality of serum lead, zinc and iron may be related to the pathogenesis of tic disorder.