蛋白质组学在肾移植急性排斥反应标志物筛选中的应用进展

尽管肾移植是治疗终末期肾病的最佳选择, 但是移植后的免疫排斥仍然是困扰临床的重大难题, 急性排斥反应是最常见的移植后免疫排斥反应。 移植医学在预防性筛查、 早期诊断、 改善预后和治疗等方 面正面临着新的特异性生物标记物的需求。 目前, 蛋白质组学的已经被广泛应用于移植医学的研究中, 血 清、 尿液中与肾移植后急性排斥反应相关生物标志物的筛选也取得越来越多的进展。 文章综述了基于质谱 技术的蛋白组学在肾移植后急性排斥反应相关的生物标志物筛选中的研究进展。

Application of Proteomics in Screening Markers of Acute Rejection in Renal Transplantation

Although kidney transplantation is the best choice for the treatment of end-stage renal disease, immune rejection after transplantation is still a major clinical problem and acute rejection is the most common immune rejection after transplantation. Transplantation medicine is facing a demand for new specific biomarkers in the preventive screening, early diagnosis, and the improving of prognosis and treatment. At present, proteomics has been widely used in the research of transplantation medicine, and a great progress has been made on the screening of biomarkers related to acute rejection after renal transplantation in serum and urine. This article reviews the research progress of screening of biomarkers related to acute rejection after renal transplantation by using proteomics based on mass spectrometry.