高流量鼻导管氧疗在高海拔性低氧血症中的应用

  目的  探讨高流量鼻导管氧疗设备在海拔高于2500 m的地区对人体的氧合的改善。  方法  征集从中等海拔高度的昆明（海拔约1891 m）快速进入较高海拔的拉萨（海拔约3650 m）的志愿者，在拉萨使用高流量鼻导管氧疗设备吸入空气，比较使用高流量鼻导管氧疗设备前、后志愿者指端脉搏血氧饱和度（SpO₂）、呼吸频率、心率、血压水平。  结果  在高原地区高流量鼻导管氧疗设备运行未出现故障，运转良好。在应用高流量鼻导管氧疗设备进行空气吸入后，随着吸入气体流量的增加，志愿者SpO₂改善，呼吸频率减低，差异有统计学意义（P < 0.05）。  结论  高流量鼻导管氧疗设备能改善高海拔地区机体的氧合同时降低呼吸做功，在高海拔性低氧血症的治疗方面存在潜在临床治疗价值。

Application of High-flow Nasal Cannula Oxygen Therapy in High-altitude Hypoxemia

  Objective  To explore the efficacy of high-flow nasal cannula oxygen therapy on oxygenation in populations at altitudes above 2500 meters.   Methods  Participants were recruited from medium-altitude Kunming （about 1891 m above sea level） to quickly enter higher altitude Lhasa （about 3650 m above sea level）. Participants inhaled air using high-flow nasal cannula oxygen therapy in Lhasa. The pulse oxygen saturation （SpO₂）, respiratory rate, heart rate and blood pressure were compared before and after the use of high-flow nasal cannula oxygen therapy .   Results  In high altitude area, the high flow nasal canula oxygen therapy went well and smoothly. After high-flow nasal catheter oxygen therapy, SpO₂ improved and respiratory rate decreased with the increase of inhaled gas flow, the difference was statistically significant （P < 0.05）. After using high-flow nasal cannula oxygen therapy equipment for air inhalation, SpO₂ improved and respiratory rate decreased with the increase of inhaled gas flow, the difference was statistically significant （P < 0.05）.   Conclusion  High-flow nasal cannula oxygen therapy not only improved participants’ oxygenation, it decreased the effort of breathing, and has potential clinical value in the treatment of high-altitude hypoxemia .