ROR1在肺腺癌组织中的表达与气腔播散相关性

目的 研究受体酪氨酸激酶样孤儿受体1(receptor tyrosine kinase-like orphan rectetpor 1,ROR1)在不同病理亚型肺腺癌组织中的表达与气腔播散（spread through air space,STAS）发生的关系。方法 收集昆明医科大学第一附属医院病理科2017年6月至2022年1月，肺腺癌组织蜡块标本618例，采用HE染色切片判断病理亚型与病理特征，记数STAS数量并分级，免疫组化染色，半定量判读ROR1表达水平，统计分析ROR1表达与STAS数量及与病理亚型的关系。结果 ROR1在微乳头型与实体型肺腺癌（低分化）中的表达高于其它亚型肺腺癌，差异有统计学意义（P <0.001）;ROR1在低STAS、高STAS组中表达率分别为88.0%、94.1%，高于无STAS组且差异有统计学意义（P <0.001）。结论 ROR1高表达于低分化肺腺癌并提示更高的STAS发生率。ROR1有望成为新的肺腺癌诊断生物标志物用于指导临床治疗及辅助预后判断，并可能成为STAS阳性肺腺癌的潜在治疗靶点。

Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace

  Objective  To study the relationship between the expression of receptor tyrosine kinase-like orphan receptor 1 （ROR1） and spread through air space （STAS） in lung adenocarcinoma tissues.   Methods  We collected 618 cases of lung adenocarcinoma from June 2017 to January 2, 2022, HE staining section was used to determine pathological subtypes and pathological characteristics, count STAS number and grade. The expression of ROR1 was detected by immunohistochemistry staining in different pathological subtypes of lung adenocarcinoma and the relationship with STAS quantity was analyzed.   Results  ROR1 expressions were higher in micropapillary and solid lung adenocarcinoma （poorly differentiated） （P < 0.001）; ROR1 expression rates were 88.0%, 94.1% in low STAS and high STAS groups, significantly higher than no STAS group （P < 0.001）.   Conclusions  ROR1 is highly expressed in poorly differentiated lung adenocarcinoma and suggests a higher incidence of STAS. ROR1 is expected to be a new diagnostic biomarker of lung adenocarcinoma for guiding clinical treatment and assisting prognostic judgment, and may be a potential therapeutic target for STAS-positive lung adenocarcinoma.