不同深度微针联合外用米诺地尔酊治疗男性雄激素性脱发的疗效观察

 目的 观察不同深度微针联合外用米诺地尔酊治疗男性雄激素性脱发的临床疗效以及安全性。方法 纳入2020年6月至2021年6月河南科技大学第一附属医院皮肤科门诊男性雄激素性脱发患者90例,随机分为A组（n=30）、B组（n=30）和C组（n=30）。A组仅外用5%米诺地尔酊治疗，B组予0.5 mm深度电动微针针刺联合外用米诺地尔酊治疗；C组予1 mm深度电动微针针刺联合外用米诺地尔酊治疗。治疗12周后观察临床疗效及不良反应情况。结果 治疗12周后,三组患者毛发密度、毛发直径均较治疗前明显改善（均P＜0.05），B组和C组均明显优于A组(均P<0.05)。B组和C组患者治疗后自我评估头发生长改善评分均明显优于A组（均P＜0.05）。A、B、C三组患者不良反应发生率分别为6.67%、6.67%和26.67%，C组明显高于A组和B组(X²=6.92,P=0.031)。结论 0.5 mm深度微针针刺联合外用米诺地尔酊治疗男性雄激素性脱发疗效显著，安全性好，是男性雄激素性脱发患者新的治疗选择。

Clinical effects of microneedling at different depths combined with external minoxidil tincture on male androgenetic alopecia

Objective To observe the clinical efficacy and safety of microneedling at different depths combined with minoxidil tincture in the treatment of male androgenetic alopecia. Methods From June 2020 to June 2021, 90 male patients with androgenetic alopecia were enrolled in the department of dermatology clinic of the first affiliated hospital of Henan university of science and technology, and they were randomly divided into the group A（n=30）, the group B（n=30）or the group C（n=30）. Patients in the group A were treated with external application of minoxidil tincture only, patients in the group B were treated with 0.5 mm deep electrodynamic microneedling combined with external application of minoxidil tincture, and patients in the group C were treated with 1 mm deep electrodynamic microneedling combined with external application of minoxidil tincture drug treatment. The clinical efficacy and adverse reactions were observed after 12 weeks treatment. Results After 12 weeks treatment, the hair densities and the hair diameters of patients in all three groups were significantly improved compared with those before treatment (all P<0.05). The hair densities and hair diameters of patients in the group B and C were significantly better than those of patients in the group A (all P<0.05). The self assessed hair growth of the patients showed that the hair growth improvement scores of patients in the group B and group C were significantly better than that of patients in the group A (all P<0.05). The incidence of adverse reactions for patients in the groups A, B, and C were 6.67%, 6.67% and 26.67%, respectively. The incidence of adverse reactions for patients in the group C was significantly higher than that in patients in other groups (2=6.92,P=0.031). Conclusion 0.5 mm deep microneedling combined with external minoxidil tincture in the treatment of male androgenetic alopecia is effective, safe, and is a new treatment option for patients with male androgenetic alopecia.