MTHFR C677T基因多态性与颈动脉狭窄及其侧支循环形成的关系

目的 研究MTHFR C677T基因多态性与颈动脉狭窄及其侧支循环形成的关系.方法 收集2018年10月至2021年3月昆明医科大学第二附属医院脑血管病科通过DSA诊断颈动脉中重度狭窄或慢性闭塞的患者65例,无明显颈动脉狭窄的对照组45例.所有患者完成一般情况评估.颈动脉中重度狭窄或慢性闭塞的65例患者DSA ASIT...

Relationship between the MTHFR C677T Gene Polymorphism and the Collateral Circulation in Patients with Carotid Stenosis

  Objective  To study the relationship between the MTHFR C677T gene polymorphism and the collateral circulation in patients with carotid stenosis.   Methods   A total of 65 patients with moderate or severe carotid stenosis and chronic occlusion diagnosed by DSA and 45 controls without carotid stenosis from October 2018 to March 2021 in our hospital were included. All patients completed general assessment. 65 patients with moderate or severe carotid stenosis and chronic occlusion were evaluated the collateral circulation ASITN grading by DSA . All patients completed MTHFR C677T genetic polymorphism test.   Results  The incidence of stroke in patients with moderate or severe carotid stenosis and chronic occlusion was significantly higher than that in control group. There were significant differences in age, smoking history, hypertension, diabetes, total cholesterol, low density cholesterol lipoprotein, homocysteine and CT/TT type of MTHFR C677T gene between carotid artery stenosis or chronic occlusion group and control group （P < 0.05）. The patients with good collateral circulation （ASITN grade 3-4） had high proportion of CC type in moderate or severe carotid stenosis and chronic carotid occlusion group. And the TT/TC type were more in patients with poor collateral circulation opening （ASITN grade 1-2） .  Conclusions  CT/TT type of MTHFR genotype is a risk factor for carotid stenosis. The collateral circulation of patients with CT/TT type is worse comparing with CC type in carotid stenosis.