银屑病与炎症性肠病的共同发病通路及靶向药物

 目前银屑病与炎症性肠病被认为是慢性系统性炎症性疾病，并且越来越多的证据表明两者互为共患病。它们在病理生理机制上有许多重叠，因而靶向这些共同发病通路的药物成为当前治疗这两种共患病的热点。本文综述银屑病与炎症性肠病中共同发病通路，包括细胞外的肿瘤坏死因子、IL-23、IL-17信号通路，以及细胞内的JAK-STAT通路、cAMP信号通路、ROR-γT/Th17轴，简要总结靶向这些共同发病通路的新兴药物，以期为临床治疗两种共患病提供一定思路。

The common pathways and targeted drugs for psoriasis and inflammatory bowel disease

The increasing evidence showed that psoriasis and inflammatory bowel disease are now considered as chronic systemic inflammatory diseases, and they are comorbidities for each other. Due to multiply overlapping pathophysiological mechanisms, drugs targeting to their common pathways have become hot spots in the current treatment of these two comorbidities. This review summarizes the common pathways involved in psoriasis and inflammatory bowel disease, including extracellular tumor necrosis factor, IL-23, IL-17 signaling pathways, as well as intracellular JAK-STAT pathway, cAMP signaling pathway, and ROR-γT/Th17 axis. Additional, this paper also briefly summarizes the drugs targeting to these common pathways. Altogether, the paper can provide some ideas for clinical treatment of these two comorbidities.