| 二甲亚砜对染毒支气管上皮细胞的保护作用分析 |
| |
| 引用本文： | 李世珍,黄波,黄锐,贺性鹏,. 二甲亚砜对染毒支气管上皮细胞的保护作用分析[J]. 中国医学工程, 2008, 16(1): 26-29 |
| |
| 作者姓名： | 李世珍 黄波 黄锐 贺性鹏 |
| |
| 作者单位： | 南华大学公共卫生学院,湖南,衡阳,421001 |
| |
| 摘 要： | 目的在观察铀矿粉对体外培养的支气管上皮细胞的毒性作用同时,加入二甲亚砜,以了解其在支气管上皮细胞受铀矿粉染毒时的可能保护机制。方法将不同浓度的铀矿粉与体外培养的支气管上皮细胞进行长时间接触,分为对照组、染毒组和二甲亚砜（DMSO）保护组,通过血清抗性实验等,观察各组间细胞受损的情况。结果随着铀矿粉浓度的增高,支气管上皮细胞受损明显加重,加入二甲亚砜的支气管上皮细胞受损情况好于未加入者。DMSO对铀矿尘作用于BEAS-2B细胞后,可引起细胞DNA断裂,造成细胞拖尾率、彗星尾部DNA含量、尾长、尾部面积、尾距增加具有较好的抑制作用。结论铀矿粉对支气管上皮细胞有明显的恶性转化作用,可能是铀矿粉对肺损伤的主要机制,二甲亚砜具有一定的保护作用。
|
| 关 键 词： | 铀矿粉 人支气管上皮细胞 二甲亚砜 |
| 文章编号： | 1672-2019(2008)01-0026-03 |
| 修稿时间： | 2007-12-05 |
The protection of DMSO to cytotoxic of human bronchial epithelial cell caused by uranium mine dust |
| |
| LI Shi-zhen,HUANG Bo,HUANG Rui,HE Xing-peng. The protection of DMSO to cytotoxic of human bronchial epithelial cell caused by uranium mine dust[J]. China Medical Engineering, 2008, 16(1): 26-29 |
| |
| Authors: | LI Shi-zhen HUANG Bo HUANG Rui HE Xing-peng |
| |
| Affiliation: | LI Shi-zhen,HUANG Bo,HUANG Rui,HE Xing-peng (Public Health College of Nanhua University,Hengyang,Hunan 421001,P.R.China) |
| |
| Abstract: | Objective The aim of this study was to explore the malignant transformation effect on cytotoxic of human bronchial epithelial cell (BEAS-2B) induced by uranium mine dust,further investigate the cause and mechanism of human lung cancer. All of these is to be researched the protection and mechanism of DMSO to cytotoxic,genotoxic,clastogenic and mutagenic which caused by uranium mine dust. Methods The immortalized human bronchial epithelial cells BEAS-2B were treated with uranium mine dust at the concentration... |
| |
| Keywords: | uranium mine dust human bronchial epithelial cells DMSO |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国医学工程》浏览原始摘要信息 |
|
点击此处可从《中国医学工程》下载全文 |
|
