促渗剂对疗筋涂膜剂中芍药苷经皮渗透的影响

目的:研究促渗剂对疗筋涂膜剂中芍药苷经皮渗透行为的影响。方法:建立离体经皮渗透试验方法,并作方法学考察。分别在涂膜剂中加入单一及复合促渗剂1%Borneol,3%Borneol,8%Borneol,1%Azone,3%Azone,5%Azone,3%1,2-Propanediol,5%1,2-Propanediol,10%1,2-Propanediol,1%Azone+8%Borneol,3%Azone+8%Borneol,5%Azone+8%Borneol,5%1,2-Propanediol+8%Borneol,5%1,2-Propanediol+8%Borneol+3%Azone和10%1,2-Propanediol+8%Borneol+5%Azone,在相同条件下进行离体经皮渗透试验,测定不同时间的药物累积透过量及增渗倍数。结果:在涂膜剂处方中加入混合促渗剂后,药物累积透过量和增渗倍数明显增加,并高于相应单用促渗剂,5%1,2-Propanediol+8%Borneol+3%Azone促渗剂累积透过量和增渗倍数最高。结论:一定量的促渗剂可使涂膜剂中药物穿透角质层进入真皮层,混合使用促渗剂促透效果明显高于单一使用。

Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares

Objective:To study the effect of penetration enhancers on the transdermal penetration of peoniflorin in the Liaojin membrares.Methods:We firstly established the experimental method of transdermal penetration,and the methodology study was carried out at the same time.Furthermore,we added 1%Borneol,3%Borneol,8%Borneol,1% Azone,3% Azone and 5% Azone,3% 1,2-Propanediol,5% 1,2-Propanediol,10% 1,2-Propanediol,1% Azone+8%Borneol,3% Azone+8%Borneol,5% Azone+8%Borneol,5% 1,2-Propanediol+8%Borneol,5% 1,2-Propanediol+8%Borneol+3% Azone and 10%1,2-Propanediol+8%Borneol+5% Azone into the membrares.The cumulative penetration amounts and anatonosis multiple were determined during the test of transdermal penetration.Results:The cumulative penetration amounts and anatonosis multiple released from the membrares increased,and the effect to use mix penetration enhancers was far superior compared with penetration enhancers alone.Conclusions:The results indicate that quantitative penetration enhancers can facilitate drug through corneum into dermis,but to use mix penetration enhancers is far superior compared with penetration enhancers alone.