Treatment-related deaths in second complete remission in childhood acute myeloid leukaemia |
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| Authors: | Lene Molgaard‐Hansen,Merja M tt nen,Heidi Glosli,Gu mundur K. J nmundsson,Jonas Abrahamsson,Henrik Hasle |
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| Affiliation: | Department of Paediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark. lene.molgaard@dadlnet.dk |
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| Abstract: | The frequency and causes of treatment-related deaths (TRD) in second complete remission (CR2) in acute myeloid leukaemia (AML) were investigated in a historical, prospective cohort study of 429 children included in the Nordic Society of Paediatric Haematology and Oncology (NOPHO)-AML-88 and -93 trials. Relapse occurred in 158 children (39%). Seventeen (18%) of the 96 patients entering CR2 suffered TRD. The main causes were infection (59%) and complications from graft-versus-host disease (22%). Fourteen (82%) of 17 TRDs occurred in children undergoing haematopoietic stem cell transplantations (HSCT). Optimal supportive care after HSCT is essential, and studies on risk factors for TRD are needed. |
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| Keywords: | acute myeloid leukaemia children treatment‐related mortality relapse infection |
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