| 慢性乙型肝炎患者不同免疫状态下外周血自然杀伤细胞亚群的特点及其临床意义 |
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| 引用本文： | 吴静,许林,刘勇,陈军浩,张勇扬,黄铭厚,熊亚莉,程健,吴超.慢性乙型肝炎患者不同免疫状态下外周血自然杀伤细胞亚群的特点及其临床意义[J].胃肠病学,2010,15(5):271-274. |
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| 作者姓名： | 吴静 许林 刘勇 陈军浩 张勇扬 黄铭厚 熊亚莉 程健 吴超 |
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| 作者单位： | 1. 南京医科大学鼓楼临床医学院感染病科,210008
2. 南京医科大学鼓楼临床医学院检验科,210008 |
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| 基金项目： | 南京市医学重点科技发展项目 |
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| 摘 要： | 背景:外周血自然杀伤细胞(NK细胞)亚群在各种病毒感染性疾病中有不同程度的改变,其在HBV感染不同免疫状态下的变化尚不明确。目的:研究慢性乙型肝炎(CHB)患者不同免疫状态下外周血NK细胞亚群的变化特点及其临床意义。方法:采用流式细胞术检测46例CHB患者(免疫耐受期25例,免疫清除期21例)和10例健康志愿者的外周血NK细胞亚群比例,采用实时荧光定量PCR技术检测血清HBV DNA载量,同时检测血清ALT水平。结果:免疫清除期CHB患者外周血CD56~(bright)NK细胞比例明显高于免疫耐受期和健康对照组,差异均有统计学意义(0.877±0.493对0.647±0.294和0.546±0.173,P0.05);三组间CD56~(dim)NK细胞比例差异无统计学意义。外周血CD56~(bright)NK细胞比例与血清HBV DNA载量在免疫耐受期呈负相关(r=-0.575,P0.05),在免疫清除期则无相关性。各组不同免疫状态下外周血NK细胞亚群比例与血清ALT水平均无相关性。结论:外周血CD56~(bright)NK细胞比例增高可能是反映CHB患者进入免疫清除期的潜在指标之一,NK细胞及其亚群在抗HBV的适应性免疫中发挥重要调节作用。
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| 关 键 词： | 肝炎 乙型 慢性 免疫耐受 杀伤细胞 天然 |
Characteristics and Clinical Significance of Peripheral Blood Natural Killer Cell Subsets in Patients with Chronic Hepatitis B during Different Immune Status |
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| WU Jing,XU Lin,LIU Yong,CHEN Junhao,ZHANG Yongyang,HUANG Minghou,XIONG Yali,CHENG Jian,WU Chao.Characteristics and Clinical Significance of Peripheral Blood Natural Killer Cell Subsets in Patients with Chronic Hepatitis B during Different Immune Status[J].Chinese Journal of Gastroenterology,2010,15(5):271-274. |
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| Authors: | WU Jing XU Lin LIU Yong CHEN Junhao ZHANG Yongyang HUANG Minghou XIONG Yali CHENG Jian WU Chao |
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| Institution: | WU Jing,XU Lin,LIU Yong,CHEN Junhao,ZHANG Yongyang,HUNAG Minghou,XIONG Yali,CHENG Jian,WU Chao.Department of Infectious Disease,Nanjing Drum Tower Hospital,Nanjing Medical University,Nanjing (210008) |
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| Abstract: | Background:Peripheral blood natural killer (NK) cell subsets change in different degree in various viral infectious diseases.However,the changes of NK cell subsets in HBV infection during different immune status have not been completely defined.Aims:To assess the characteristics and clinical significance of NK cell subsets in peripheral blood in chronic hepatitis B (CHB) patients during different immune status.Methods:Forty-six patients with CHB including 25 patients in immune-tolerance phase and 21 patient... |
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| Keywords: | Hepatitis B Chronic Immune Tolerance Killer Cells Natural |
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