Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs |
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Authors: | Ambrogi Valeria Fardella Giuseppe Grandolini Giuliano Nocchetti Morena Perioli Luana |
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Affiliation: | Dipartimento di Chimica e Tecnologia del Farmaco, via del Liceo 1, University of Perugia, 06123 Perugia, Italy. |
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Abstract: | A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH < 4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin. |
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