依托咪酯对普鲁卡因、丁卡因致惊厥半数有效量的影响

目的：观察依托咪酯对普鲁卡因、丁卡因致惊厥半数有效量的影响。方法：将64只小鼠随机分为4组（n=16）,分别为普鲁卡因组、丁卡因组、依托咪酯＋普鲁卡因组、依托咪酯＋丁卡因组。实验小鼠均采用腹腔注射的给药方法,用序贯法测各组惊厥的半数有效量。结果：与普鲁卡因组比较,依托咪酯＋普鲁卡因组致惊厥ED50显著提高（P〈0.01）;与丁卡因组比较,依托咪酯＋丁卡因组致惊厥的半数有效量显著提高（P〈0.01）。结论：预先给一定剂量的依托咪酯可以提高普鲁卡因或丁卡因致惊厥阈值,说明依托咪酯对局麻药引起的惊厥有一定的防治作用。

The Influence of Etomidate on Convulsant ED50 Induced by Chlorprocaine and Ropivacaine in Mice

Objective：To observe the influence of etomidate on convulsion ED50 （ 50%. effective dose ） induced by chlorprocaine and ropivacaine in mice. Methods：64 mice were randomly divided into four groups （n = 16 ） ： chlorprocaine group, ropivacaine group, etomidate ＋ chlorprocaine group, etomidate ＋ ropivacaine group. The mice were administrated by intraperitoneal injection （ ip ） and the convulsant ED50 was determined by sequential method. Results： Compared with chlorprocaine group, the convulsant EDs0 of etomidate ＋ chlorproeaine group was increased apparently （P 〈 0. 01 ） ; compared with ropivacaine group, the convulsant ED50 of etomidate ＋ ropivacaine group was increased significantly （ P 〈 0. 01 ）. Conclusions ： Pior to administration by some etomdiate can increase the convulsant threshold of chlorprocaine or ropivaeaine that is etomdiate can prevent the convulsant effects induced by local anesthetics to some extent.