鱼油脂肪乳对胃肠道恶性肿瘤病人术后营养状况和体液免疫的影响

目的:观察鱼油脂肪乳对胃肠道恶性肿瘤病人术后营养状况和体液免疫的影响. 方法: 将30例胃肠道恶性肿瘤病人随机分为研究组和对照组,每组15例.术后两组病人使用等氮、等热量的PN支持,研究组添加鱼油脂肪乳.于术前、术后第1天和第6天分别检测血肝肾功能、血脂、Hb、ALB、TF、淋巴细胞计数(TLC)、B淋巴细胞亚群(B1、B2)、免疫球蛋白(IgG、IgM、IgA)和补体(C3、C4)水平. 结果: 两组病人术后第6天肝肾功能、血脂水平与术前相比均无显著性差异.研究组病人术后第6天TLC、IgG、IgM、C3显著高于对照组(P<0.05).两组病人Hb、ALB、TF和B淋巴细胞亚群无显著性差异. 结论: 胃肠道恶性肿瘤病人术后使用鱼油脂肪乳安全可耐受,能提高体液免疫功能,但在短期内病人的营养状况未见改善.

The effects of fish oil fat emulsion on nutritional status and humoral immunity in postoperative patients suffering from gastrointestinal malignancy

Objective: To investigate the effects of ω-3 fish oil fat emulsion on nutritional status and humoral immunity in postoperative patients suffering from gastrointestinal malignancy. Methods: Thirty patients of gastrointestinal malignancy were randomly divided into study group (n = 15) and control group (n = 15). All the patients were assigned to receive total parenteral nutrition with the equal nitrogen and calory,and those in study group received fish oil fat emulsion additionally. Liver and renal function, blood lipid, haemoglobin, albumin, transferrin, total lymphocyte count (TLC) , B lymphocyte subsets (B1, B2), immunoglobin(IgG, IgM, IgA) and complement(C3, C4) were determined preoperatively and 1, 6d postoperatively. Results: There were no significant differences in liver and renal function and blood lipid on postoperative day 6 versus preoperation in all the two groups. TLC, IgG, IgM, C3 on postoperative day 6 were siginificantly higher in the study group(P < 0. 05). Haemoglobin, albumin, transferrin and B lymphocyte subsets were not significantly different between the two groups. Conclusion: Fish oil fat emulsion treatment was safe and tolerated, and could improve the humoral immunity in patients.