Delirium Development After Lung Transplantation: An Intraoperative Assessment |
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| Institution: | 1. Department of Anesthesiology and Reanimation, Ankara City Hospital, University of Health Sciences, Ankara, Turkey;2. Department of General Thoracic Surgery and Lung Transplantation, Ankara City Hospital, University of Health Sciences, Ankara, Turkey;1. Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands;2. Laboratory of Medical Immunology, Department of Immunology, Erasmus MC University Medical Center, Rotterdam, The Netherlands;3. Erasmus MC Transplant Institute, Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands;1. Department of Organ Transplantation Center, The First Affiliated Hospital of University of Science and Technology of China, He Fei, China;2. Department of Organ Procurement Organization, The First Affiliated Hospital of University of Science and Technology of China, He Fei, China;3. China Organ Transplant Response System (COTRS), National Health Commission of the People''s Republic of China, Beijing, China;4. Department of Biliary and Pancreatic Surgery, The First Affiliated Hospital of University of Science and Technology of China, He Fei, China;1. Department of Obstetrics and Gynecology, the Sixth Medical Center, PLA General Hospital, BeiJing, China;2. Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, BeiJing, China;1. Department of Biomedical Ethics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;2. Division of Urology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan;3. Department of Transplantation Medicine, Kobe University Hospital, Kobe, Japan |
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| Abstract: | BackgroundThis study aimed to evaluate the relationship between intraoperative hemodynamic and laboratory parameters with postoperative delirium development after lung transplantation.MethodsA total of 77 patients who underwent lung transplantation in a single center were included in the study. Demographic and clinical data recorded at critical intraoperative stages (after induction T1], after bilateral lungs are dissected T2], while the patient is ventilated for 1 lung T3], while the unilateral transplanted lung is ventilated T4], while bilateral transplanted lungs are ventilated T5], and after the thorax is closed T6]), postoperative complications, mechanical ventilation duration, intensive care, and hospitalization durations and mortality rates were recorded.ResultsA total of 83.1% of the 77 patients were male, and the mean (SD) age was 47.56 (12.95) years. The mean body mass index (calculated as weight in kilograms divided by height in meters squared) was 23.30 (3.99), and the median Charles Comorbidity Index (CCI) was 1. The diagnosis of 36.4% of the patients was chronic obstructive pulmonary disease. Delirium was seen in 51.9% of the patients. Age, CCI, intraoperative mean arterial pressure changes, lactate levels, mechanical ventilation duration, and hospital stay were all associated with delirium development.ConclusionAge, CCI, duration of mechanical ventilation, and hospital stay were independent predictors of postoperative delirium development. We believe that our study will be a guide for future prospective randomized controlled studies. |
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