Association of Lifestyle Behaviors With Hearing Loss: The UK Biobank Cohort Study |
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| Affiliation: | 1. Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid and CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain;2. IMDEA-Food Institute, CEI UAM+CSIC, Madrid, Spain;1. School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan;2. Department of Obstetrics and Gynecology, Taipei Medical University, Taipei City, Taiwan;3. Graduate Institute of Clinical Pharmacy and School of Pharmacy, College of Medicine, National Taiwan University;4. Department of Pharmacy, National Taiwan University Hospital;5. Departments of Population Health and Radiation Oncology, University of Kansas School of Medicine, Kansas City, KS, USA;6. Department of Radiation Oncology, University of Kansas School of Medicine, Kansas City, KS, USA;7. Department of Obstetrics and Gynecology, Taipei Medical University Hospital;1. Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN, USA;2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA;3. Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA;4. Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA;1. Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA;2. Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA;3. Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA;1. Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan;2. Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan;3. College of Medicine, Chang Gung University, Taoyuan, Taiwan;4. Department of Gastroenterology & Hepatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan;5. Taiwan Association of the Study of Small Intestinal Disease, Taoyuan, Taiwan;6. Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan |
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| Abstract: | ObjectiveTo examine the combined association of five healthy lifestyle behaviors with hearing loss (HL) in the UK Biobank cohort, established between 2006 and 2010 in the United Kingdom.MethodsThis longitudinal analysis included 61,958 participants aged 40 to 70 years from April 2007 to December 2016. The healthy behaviors examined were: never smoking, high level of physical activity, high diet quality, moderate alcohol intake, and optimal sleep. Hearing loss was self-reported at baseline and in any physical exam during the follow-up.ResultsOver a median follow-up of 3.9±2.5 years, 3072 (5.0%) participants reported incident HL. After adjustment for potential confounders, including age, social factors, exposure to high-intensity noise, ototoxic medication, and comorbidity, the HRs of HL associated with having 1, 2, 3, and 4 to 5 vs 0 behaviors were: 0.85 (95% CI, 0.75 to 0.96), 0.85 (95% CI, 0.75 to 0.96), 0.82 (95% CI, 0.71 to 0.94), and 0.80 (95% CI, 0.67 to 0.97), respectively (P for trend, 0.02). We estimated that the population attributable risk percent for not adhering to any five low-risk lifestyle behaviors was 15.6%.ConclusionIn this large study, an increasing number of healthy behaviors was associated with decreased risk of HL. |
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