Novel antibacterial dental resin containing silanized hydroxyapatite nanofibers with remineralization capability |
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Institution: | 1. Department of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China;2. Research Institute of Polymer Materials, School of Materials Science and Engineering, Shandong University, Jinan 250061, China |
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Abstract: | ObjectivesSecondary caries is the primary issue that causes restoration failure. The objectives of this study were to: (1) synthesize silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM); (2) evaluate the mechanical property, antibacterial activity, and remineralization capability of the novel dental resin containing s-HAFs@EM.Methodss-HAFs were prepared by the solvothermal approach and loaded with EM. Characterization and antibacterial activity were evaluated. Subsequently, s-HAFs@EM were incorporated into dental resin at different mass fractions (5 %, 10 %, 15 %, and 20 %), and then they were submitted to characterization, including mechanical property, antibacterial activity, remineralization capability, and cytotoxicity.Resultss-HAFs@EM were successfully synthesized, and they exhibited excellent antibacterial activity. Resin containing 15 % s-HAFs@EM exhibited the best flexural strength (118.67 ± 15.71 MPa) and elastic modulus (2.02 ± 0.30 GPa) (P < 0.05), which were increased by 65.43 % and 90.7 %, compared to those of neat resin, respectively. Resin with 15–20 % s-HAFs@EM showed high antibacterial rate (>85 %) when compared control group (P < 0.05). Furthermore, resin also exhibited a definite remineralization capability and good biosafety in vitro.SignificanceThis novel multifunctional resin with improved mechanical property, desirable antibacterial activity and remineralization capability is promising to combat secondary caries. |
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Keywords: | Hydroxyapatite nanofibers Silanization Erythromycin Resin Mechanical property Antibacterial Remineralization |
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