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Importance of Preventing Inadvertent Perioperative Hypothermia During Liver Transplant
Affiliation:1. Liver transplantation Unit, Gastroenterology Department, Hospital Universitario Rio Hortega, Valladolid, Spain;2. Department of Pathology, Hospital Universitario Rio Hortega, Valladolid, Spain;1. HBP Surgery and Transplantation Department, Hospital Universitario Vall d''Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain;2. Department of Pediatric Surgery, Hospital Universitario Vall d''Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain;3. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain;1. Kidney Transplant Unit, Department of Nephrology, Hospital Universitario La Fe, Valencia, Spain;2. Valencian Community Blood Transfusion Center, Valencia, Spain;3. IIS La Fe - Medical Research Institute Hospital La Fe, Hospital Universitario La Fe, Valencia, Spain;1. Nephrology Service, University Hospital Marqués de Valdecilla/IDIVAL, Santander, Cantabria, Spain;2. Clinical Pharmacology Service, University Hospital Marqués de Valdecilla/IDIVAL, Santander, Spain;3. University of Cantabria, Santander, Spain
Abstract:BackgroundInadvertent perioperative hypothermia (IPH) leads to a series of deleterious effects that can be especially in complex procedures such as liver transplant. The implementation of a protocol is key to ensure the patient's normothermia.MethodsA cohort of 209 patients who underwent liver transplant in a tertiary hospital in a period between January 2016 and December 2018 was retrospectively analyzed. The patients were divided into 2 groups: group 1, patients with normothermia (core body temperature ≥ 36°C) and group 2, patients with hypothermia (core body temperature < 36°C). Mortality between both groups at 1 month, 1 year, and 3 years is compared. Postoperative morbidity is also compared.ResultsThe incidence of IPH is 21.5%. Patients with normothermia present with statistical significance: a lower mortality at 1 year; a lower need for transfusion of platelets, plasma, fibrinogen consumption, or massive polytransfusion; and lower primary graft dysfunction, graft and surgical complications, rejection, hemodynamic complications, and metabolic and surgical reintervention.No significant differences were found in mortality at 1 month or 3 years in the need for prolonged mechanical ventilation; hospital readmission; length of stay in the intensive care unit or in hospital stay; rate of red blood cell transfusion; vascular, biliary, respiratory, or digestive complications; refractory ascites; or neurologic, kidney, hematological, endocrine, thrombotic, nutritional, or infectious issues.ConclusionsThe incidence of IPH is relatively low in our patients, based on what is described in the literature, and in most cases it is mild. There is a reduction in complications fundamentally related to the consumption of blood products and the graft.
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