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Minimally invasive cerebral revascularization in moyamoya disease in adult patients
Affiliation:1. Department of Neurological Surgery, University of California, San Francisco, San Francisco, California;2. Department of Neurosurgery, The George Washington University, Washington, District of Columbia, United States;3. Department of Radiation Oncology, The George Washington University, Washington, District of Columbia, United States;4. Rockefeller Neuroscience Institute, Department of Neurosurgery, West Virginia University, Martinsburg, West Virginia;1. Department of Neurosurgery, Department of NEUROFARBA, Careggi University Hospital, University of Florence, Florence, Italy;2. Department of Neurophysiopathology, Careggi University Hospital, Florence, Italy;3. Neurological Rehabilitation Unit, IRCCS Don-Carlo-Gnocchi Foundation, Florence, Italy;1. Division of Neurosurgery, Department of Surgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, 8440 112, Street NW, Edmonton, Alberta T6G 2B7, Canada;2. Division of Neurology, Department of Medicine, University of Alberta Hospital, Mackenzie Health Sciences Centre, 8440 112, Street NW, Edmonton, Alberta T6G 2B7, Canada;3. Department of Radiology, Centre Hospitalier de l’Université de Montréal (CHUM), 1000, St–Denis Street, room D03.5462B, Montreal H2X 0C1, Quebec, Canada;1. Department of Spine Surgery, P. Hospices Civils de Lyon, Wertheimer University Hospital, Claude Bernard University of Lyon 1, Lyon, France;2. Laboratory of Biomechanics, Arts et Metiers ParisTech, 151, boulevard de l’Hôpital, 75013 Paris, France;1. Department of Neurosurgery, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic;2. Department of Neuroradiology, Military University Hospital, Prague, Czech Republic
Abstract:BackgroundMoyamoya disease (MMD) affects young patients, is generally progressive, and results in strokes or cerebral hemorrhages for which medical management is not effective.ObjectiveTo determine the effectiveness of surgical management with minimally invasive cerebral revascularization in MMD.Material and MethodsWe conducted a retrospective cohort study of patients undergoing extracranial-intracranial microsurgical revascularization surgery with mini-craniotomy, analyzing the epidemiological, clinical, neuroimaging, postoperative evolution, and complications. We describe the technique in detail. Key outcomes included graft patency, complications, and recurrence of ischemic or hemorrhagic stroke.ResultsFrom September 2017 to December 2020, 12 brain revascularization procedures for MMD were performed in eight patients (four bilateral), and all 12 grafts were classified as patent. The main complication was contralateral cerebral infarction identified by postoperative neuroimaging in a patient without clinical symptomatology. There was no case of scalp ischemia or necrosis when performing the minimally invasive approach with linear incision.ConclusionsThe results of this study suggest that the minimally invasive extracranial-intracranial cerebral revascularization procedure for MMD in adults is effective, with graft patency in all cases and minimal morbidity.
Keywords:Moyamoya disease  Cerebral revascularization  Bypass  Minimal invasive
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