A comparative study to evaluate efficacy,safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin |
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| Authors: | Saket J. Thaker Dimple S. Mehta Hiral A. Shah Jayendra N. Dave Kunjan M. Kikani |
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| Affiliation: | Department of Pharmacology, C.U. Shah Medical College, Surendranagar, Gujarat, India;1.Department of Dermatology Venereology and Leprology, C.U. Shah Medical College, Surendranagar, Gujarat, India;2.Department of Microbiology, C.U. Shah Medical College, Surendranagar, Gujarat, India |
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| Abstract: | Aims and Objectives:The aim of this study is to compare the efficacy, safety and cost-effectiveness of topical Whitfield''s ointment plus oral fluconazole with topical 1% butenafine in tinea infections of the skin.Materials and Methods:Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield''s ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up.Results:Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield''s ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated patients reduced it from 8.88 ± 0.53 to 0.31 ± 0.67 at the end of the treatment. Nearly, 98% patients were completely cleared of the lesion on the 3rd follow-up with both treatments.Conclusion:Whitfield''s ointment with oral fluconazole is as efficacious, safe and cost-effective as compared with 1% butenafine in tinea infections of the skin.KEY WORDS: Butenafine, fluconazole, tinea infections, Whitfield''s ointment |
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