Hepatic Angiosarcoma Post-Renal Transplantation: A Case Report |
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| Institution: | 1. Department of Pharmacy, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan;2. Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan;3. Department of Surgery, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan;4. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan;5. Division of Urology, Department of Surgery, St. Martin De Porres Hospital, Chia-Yi City, Taiwan;1. Nephrology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal;2. Nephrology Department, Hospital Beatriz Ângelo, Loures, Portugal;3. Nephrology Department, Centro Hospitalar Universitário de São João, Porto, Portugal;4. Hematology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.;1. Internal Medicine, Indiana University School of Medicine, Indianapolis, IN, USA;2. Advanced Heart Failure Division, Cardiovascular Medicine, Indiana University School of Medicine, Indianapolis, IN, USA;3. Clinical Medicine Division, Cardiovascular Medicine, Indiana University School of Medicine, Indianapolis, IN, USA;4. Clinical Surgery, Indiana University School Of Medicine, Indianapolis, IN, USA;1. Recanati-Miller Transplantation Institute, the Icahn School of Medicine at Mount Sinai, New York City, New York;2. Division of Transplantation Surgery, Department of Surgery, State University of New York Downstate Health Sciences University, Brooklyn, New York;3. Division of General Surgery, Department of Surgery, Mount Sinai School of Medicine, New York City, New York;1. Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;2. Ramathibodi Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;3. Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand |
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| Abstract: | BackgroundDNA damage and oncogenic viruses increase the risk of cancer post-kidney transplantation, including skin cancer, Kaposi's sarcoma, oral cancer, and non-Hodgkin lymphoma. Here we report an uncommon case of liver angiosarcoma that occurred 8 years after kidney transplantation. This study strictly complied with the Helsinki Congress and the Istanbul Declaration regarding donor source.Case reportA 57-year-old female patient received a cadaver kidney transplantation 8 years ago. She followed a long-term regimen of tacrolimus, mycophenolate sodium, and everolimus, with good renal function. She received annual regular abdominal ultrasound examinations after kidney transplantation, which showed no findings. The patient suffered from several symptoms for approximately 2 weeks before a scheduled abdominal ultrasound: diarrhea, epigastric pain, abdominal fullness, tea-colored urine, and little stool passage. The abdominal computerized tomography showed multiple hepatic tumors in both the hepatic lobes with engorged vasculatures and mild hemoperitoneum. A liver biopsy revealed the histopathology of angiosarcoma. The patient suffered multiple organ failure within one month of treatment.ConclusionsVarious post-transplant malignancies are not uncommon after transplantation, warranting periodic screenings for any symptoms in these patients. |
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