Antinuclear antibodies positivity is not rare during multiple sclerosis and is associated with relapsing status and IgG oligoclonal bands positivity |
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| Affiliation: | 2. Neurology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;1. Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;2. Neurology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;1. Service de Neurologie, AP–HP, Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France;2. Consultation-Liaison Psychiatry and Psychiatric Emergency Department, Toulouse University Hospital, Toulouse, France;3. Pole de psychiatrie universitaire du grand Nancy, Centre Psychothérapeutique de Nancy, Laxou, France;4. Department of Neurology, Princess Alexandra Hospital, Brisbane, QLD, Australia;5. University of Queensland, Brisbane, QLD, Australia;6. ANAINF (Association Nationale des Assistants et Internes de Neurologie de France), France;7. Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, College de France, CNRS UMR7241/INSERM U1050, Université PSL, 75005 Paris, France;8. Institut du Cerveau et de la Moelle épinière - ICM, Inserm U1127, CNRS UMR 7225, Sorbonne Université, 75013 Paris, France;1. CEDOC, Chronic Diseases Research Center, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Portugal;2. Department of Neurology, Hospital de Egas Moniz Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal;3. NOVA Medical School, Faculdade de Ciências Médicas Universidade Nova de Lisboa, Lisbon, Portugal;1. Department of Anesthesiology and Surgical Intensive Care, CHRU-Nancy, Université de Lorraine, 54000 Nancy, France;2. Department of Diagnostic and Therapeutic Neuroradiology, 54000 Nancy, France;3. Inserm U1254, IADI, Université de Lorraine, 54000 Nancy, France;4. Aristotle University of Thessaloniki, Ahepa Hospital, Thessaloniki, Greece;5. Department of Diagnostic and Interventional Neuroradiology, Versailles Saint-Quentin en Yvelines University, Foch Hospital, Suresnes, France;6. Department of Neurology, Versailles Saint-Quentin en Yvelines University, Foch Hospital, Suresnes, France;7. Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France;8. Inserm 1087, Department of Diagnostic and Therapeutic Neuroradiology, University Hospital of Nantes, CNRS, University of Nantes, Nantes, France;9. Diagnostic and Interventional Neuroradiology, University Hospital of Bordeaux, Bordeaux, France;10. Department of Neurology, Stroke Center, University Hospital of Bordeaux, Bordeaux, France;11. Department of Neuroradiology, University Hospital of Rennes, Rennes, France;12. Stroke Unit, Department of Neurology, University Hospital of Rennes, Rennes, France;13. Department of Interventional Neuroradiology, CHRU Gui-de-Chauliac, Montpellier, France;14. Department of Neurology, CHRU Gui-de-Chauliac, Montpellier, France;15. Stroke Unit, Department of Neurology, CHRU-Nancy, Université de Lorraine, 54000 Nancy, France;p. CIC 1433 Plurithematic, Nancy University Hospital, Université de Lorraine, Nancy, France;q. Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada;1. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Neuroscience, Milano, Italy;2. Università degli studi di MIlano, Milano, Italy;3. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pediatric Rheumatology, Milano, Italy;1. Department of Physical Medicine and Rehabilitation, Mubarak Al-Kabeer Hospital, 43753 Jabriya, Kuwait;2. Department of Medicine, Faculty of Medicine, Kuwait University, 43753Jabriya, Kuwait;3. Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of British Columbia, V6T 1Z3 Vancouver, British Columbia, Canada;4. GF Strong Rehabilitation Centre, Vancouver, V5Z 2G9 British Columbia, Canada |
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| Abstract: | IntroductionAs an immune-mediated disease of the central nervous system, multifaceted aspects of a humoral immune response are widely described during multiple sclerosis (MS). However, the prevalence of different auto-antibodies, such as antinuclear antibodies (ANA), during MS is very variable and their clinical relevance remains controversial. Our aim was to evaluate the prevalence and clinical correlations of ANA positivity in South Tunisian MS patients.Material and methodsWe performed ANA screening using indirect immunofluorescence (IIF) on HEp-2 cells (Biosystems®) in 82 MS patients. For ANA positive samples (titer ≥1/160), anti-ds-DNA detection (IIF on Crithidia luciliae (Biosystems®)) and extractable nuclear antigen typing (immunodot (Euroimmun®)) were performed.ResultsANA were positive in 35/82 MS patients (42.7%). The titer was ≥ 1/320 in 16/35 patients. The antigenic specificity of ANA was identified in 7/35 patients. None of the patients had extra-neurological manifestations. No correlation was found between ANA and age, gender, MS course, disease duration, disability, annual relapse rate nor IgG index. ANA positivity was more frequent in patients with IgG oligoclonal bands (OCB) (47.1%) than in patients without IgG OCB (16,6%) (p = 0.049). Regarding disease activity, ANA positivity was significantly more frequent in patients with relapse (52.6%) than in patients in remission (25.9%) (p = 0.031).ConclusionOur results showed that ANA positivity in MS disease is not rare. This positivity was not associated with clinical expression of any connective tissue disease. ANA occurrence in MS was associated with IgG OCB+ profile and relapsing status, probably reflecting an ongoing immune dysregulation. |
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| Keywords: | Multiple sclerosis Antinuclear antibodies IgG oligoclonal bands |
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