Posttransplant-Alloantibodies Against MICA Antigens Associated With Decreased Long-Term Allograft Survival of Kidney Transplant Recipients |
| |
| Affiliation: | 1. Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China;2. Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, Changsha, Hunan, China;3. Medical College, Hebei University of Engineering, Handan, Hebei, China;4. Department of Immunology, Xiangya School of Medicine, Center South University, Changsha, Hunan, China;1. The Second Clinical Medical College of Lanzhou University, Lanzhou, 730030, China;2. Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, 730030, China;1. Department of Nephrology, Mayo Clinic Phoenix, Arizona;2. Research Institute, Baylor Scott and White Health, Temple, Texas;3. Colorado Center for Transplantation Care, Research and Education (CCTCARE), University of Colorado, Aurora, Colorado;1. Department of Anesthesiology and Reanimation, Ankara City Hospital, University of Health Sciences, Ankara, Turkey;2. Department of General Thoracic Surgery and Lung Transplantation, Ankara City Hospital, University of Health Sciences, Ankara, Turkey;1. School of Medicine, Wayne State University, Detroit, Michigan;2. Department of Surgery Transplant, Henry Ford Health Systems, Detroit, Michigan;3. Department of Pharmacy, Henry Ford Health Systems, Detroit, Michigan;4. Department of Gastroenterology, Henry Ford Health Systems, Detroit, Michigan;1. Department of Surgery, Royal North Shore Hospital, Sydney, Australia;2. Specialty of Surgery, FMH, University of Sydney, Sydney, Australia;3. Department of Surgery, Westmead Hospital, Sydney, Australia;4. Transplant Surgery, Westmead Hospital, Sydney, Australia;5. Surgical Innovations Unit, Westmead Hospital, Sydney, Australia;6. University of Sydney, Sydney, Australia;7. Renal Transplant Unit, Westmead Hospital, Sydney, Australia;8. Intensive Care Unit, Westmead Children''s Hospital, Sydney, Australia;1. State Institution “Heart Institute of the Ministry of Health of Ukraine”, Kyiv, Ukraine;2. Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine |
| |
| Abstract: | BackgroundPrevious evidence showed that antibodies against major histocompatibility complex class I-related chain A (MICA) could lead to antibody-mediated rejection in kidney transplantation in case where the patients had no alloantibodies against HLA. However, the effects of posttransplant anti-MICA antibodies on long-term renal allograft survival and function remained unsettled. We tested the posttransplant anti-MICA antibodies in 150 kidney transplant patients. The aim of this study was to compare the long-term graft survival and function between patients who were MICA positive and those who were negative.MethodsThe posttransplant serum samples from 150 patients receiving kidney transplantation in our center from 2012 to 2013 were tested for MICA antibodies and HLA antibodies by Luminex single antigen array technology. Graft survival and function were followed up for a mean time of 74.2 months. The research was conducted in accordance with the Helsinki Congress and the Declaration of Istanbul.ResultsOf the 150 patients, 38 (25.3%) were sensitized against MICA after transplantation. The anti-MICA antibodies-positive (anti-MICA+) group had a worse long-term renal allograft survival than that of anti-MICA-negative (anti-MICA–) group (P = .029), even when stratified by posttransplant HLA sensitization status or donor source. Anti-MICA antibodies also had a detrimental impact on renal allograft function, but only at 1 year posttransplantation (estimated glomerular filtration rates at 1 year: anti-MICA+ 66.6 mL/min/1.73 m2 vs anti-MICA– 78.7 mL/min/1.73 m2; P = .023).ConclusionPosttransplant anti-MICA antibodies were associated with decreased long-term renal allograft survival and short-term renal allograft function. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
