Endometrial Cancer After Pancreas-After-Kidney Transplantation: A Case Report and Review of the Literature |
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| Affiliation: | 1. Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;2. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;3. Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;4. Department of Urology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;1. Department of Urology, Yamagata University Faculty of Medicine, Yamagata, Japan;2. Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan;1. Department of Surgery, Incheon St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;2. Department of Surgery, Seoul St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;1. Nuclear Medicine Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia;2. Nuclear Medicine Department, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia;3. Nephrology Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia;1. Department of Surgery, Seoul St. Mary''s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea;2. Department of Surgery, Bucheon St. Mary''s Hospital, College of Medicine, Catholic University of Korea, Bucheon, Republic of Korea;1. Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan;2. Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan;1. Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;2. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan |
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| Abstract: | BackgroundAs the number of long-term survivors after organ transplantation increases, malignancy has become a problem as a late complication. We herein report a case of endometrial cancer during the follow-up of pancreas transplantation after kidney transplantation.Case PresentationA 49-year-old woman was diagnosed with endometrial cancer. The patient had developed type 1 diabetes at 8 years old and started insulin treatment, and at 29 years old, she started hemodialysis for diabetic nephropathy. At 31 years old, she received living donor kidney transplantation and withdrew from dialysis. Hypoglycemia unawareness began to occur frequently from around 36 years old, and at 48 years old, the patient underwent deceased donor pancreas transplantation after kidney transplantation and achieved insulin independence. At 49 years old, she was diagnosed with endometrial cancer. Surgical treatment (total abdominal hysterectomy with left salpingo-oophorectomy) was performed. The pathologic diagnosis was confirmed as stage 1A uterine endometrioid carcinoma grade 1. The postoperative course was uneventful. She was discharged from our hospital on postoperative day 8. There has been no evidence of recurrence and/or metastasis of endometrial cancer for 16 months since the surgery.ConclusionsCarcinogenesis after pancreas transplantation may be a lethal late complication. It is important to carry out regular screening examinations with carcinogenesis in mind. |
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