Large artery intracranial stenosis in young adults with ischaemic stroke |
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| Affiliation: | 1. Département de neurologie, hôpital Pierre Paul Riquet, université de Toulouse, place du Docteur Baylac, TSA 40031, 31059 Toulouse cedex 09, France;2. Service de neuroradiologie diagnostique et thérapeutique, hôpital Pierre Paul Riquet, université de Toulouse, Toulouse, France;1. Service de neurologie, université Sorbonne Paris-Nord, hôpital Avicenne, AP–HP, Bobigny, France;2. CNRS UMR7241/INSERM U1050, Dynamic and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, collège de France, université PSL, Paris, France;1. Department of Neurology, University Hospital of Toulouse, 31059 Toulouse cedex 9, France;2. Centre de Ressources et de Compétences Sclérose en plaques, University Hospital of Toulouse, 31059 Toulouse cedex 9, France;3. Inserm UMR1291 - CNRS UMR5051, University Toulouse 3, University Hospital of Toulouse, 31024 Toulouse cedex 3, France |
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| Abstract: | Large artery intracranial stenosis (ICS) is a common finding in stroke patients, but is much less prevalent in Western countries than in Asia and in young adults than in the elderly. We investigated the prevalence and causes of ICS among French young adults with ischaemic stroke. Clinical and radiological data of patients aged 18–54 years treated consecutively for acute ischaemic stroke in the anterior circulation at a tertiary stroke centre were analysed retrospectively. Patients with > 50% ICS were identified. ICS was evaluated using TOF-MRA, vessel wall-MRI, digital subtraction angiography and CT-angiography. A total of 316 patients were included. ICS was diagnosed in 29 patients, resulting in a prevalence of 9.2% (95% CI, 6.2 to 13.3). The leading cause of ICS was atherosclerosis (n = 13), ahead of moyamoya disease (n = 4), dissection (n = 2), vasculitis (n = 2), and reversible cerebral vasoconstriction syndrome (n = 1). The cause of ICAS could not be determined in 7 patients. ICS was found in nearly one in 10 ischaemic strokes among French young adults. Atherosclerosis was the leading cause of ICS. The cause of ICS could not be determined in almost a quarter of the patients. |
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| Keywords: | Stroke Etiology Young Intracranial artery stenosis Atherosclerosis Moyamoya disease |
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