白细胞介素-2受体和CD4+/CD8+对狼疮性肾炎 活动性的相关研究

目的 探讨狼疮性肾炎（lupus nephritis，LN）患者血清白细胞介素-2受体（interleukin-2 receptor，IL-2R）、CD4+/CD8+与疾病活动性的相关性。方法 选取2021年3月至2022年12月于浙江中医药大学附属杭州市中医院就诊的38例LN患者纳入LN组，同期于本院体检健康者40名为健康对照组。收集受试者的一般临床资料、系统性红斑狼疮疾病活动指数（systemic lupus erythematosus disease activity index，SLEDAI）及病理分型；根据SLEDAI评分将LN患者分为活动组和非活动组，比较两组患者的临床指标差异。结果 LN组患者的血红蛋白（hemoglobin，Hb）、血小板计数、白蛋白（albumin，ALB）、补体C3和C4水平均显著低于健康对照组，抗核抗体和抗双链DNA抗体（anti-double strand DNA antibody，抗ds-DNA抗体）阳性率、C反应蛋白、血肌酐（serum creatinine，SCr）水平均显著高于健康对照组（P<0.05）。活动组患者的ALB显著低于非活动组，IL-2R、红细胞沉降率、24h尿蛋白定量、抗ds-DNA抗体阳性率均显著高于非活动组（P<0.05）。LN患者血清IL-2R水平与SLEDAI、SCr、血尿素氮、24h尿蛋白定量均呈正相关，与Hb、补体C3均呈负相关（P<0.05）。结论 血清IL-2R可作为判断LN活动程度的指标，为临床疾病活动的判断提供依据。

Correlation between interleukin-2 receptor and CD4+/CD8+ on the activity of lupus nephritis

Objective To investigate the correlation between serum interleukin-2 receptor (IL-2R), CD4+/CD8+ and disease activity in patients with lupus nephritis (LN). Methods A total of 38 patients with LN who were treated in Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from March 2021 to December 2022 were enrolled in LN group, and 40 healthy persons who underwent physical examination in the hospital during the same period were included in healthy control group. General clinical data, systemic lupus erythematosus disease activity index (SLEDAI) and pathological classification were collected. LN patients were divided into active group and inactive group according to SLEDAI score, and the difference of clinical indicators between two groups was compared. Results The hemoglobin (Hb), platelet count, albumin (ALB), complement C3 and C4 in LN group were significantly lower than those in healthy control group, the positive rates of antinuclear antibody and anti-double strand DNA antibody (anti-ds-DNA antibody), serum creatinine (SCr) and C-reactive protein were significantly higher than those in healthy control group (P<0.05). The ALB of active group was significantly lower than that of inactive group, and IL-2R, erythrocyte sedimentation rate, 24h urinary protein quantity and anti-ds-DNA antibody positive rate were significantly higher than those of inactive group (P<0.05). Serum IL-2R levels in LN patients were positively correlated with SLEDAI, SCr, blood urea nitrogen and 24h urinary protein quantity, and negatively correlated with Hb and complement C3 (P<0.05). Conclusion Serum IL-2R can be used as an indicator to judge the degree of LN activity and provide a basis for the judgment of clinical disease activity.