孟鲁司特钠联合奥洛他定治疗慢性荨麻疹的效果

目的 探讨孟鲁司特钠联合奥洛他定治疗慢性荨麻疹的效果。方法 选择2020年11月-2023年11月天津市河西区天塔街社区卫生服务中心收治的慢性荨麻疹患者86例，根据治疗方案不同将患者分为对照组和研究组，各43例。对照组给予奥洛他定单一用药，研究组给予孟鲁司特钠与奥洛他定联合用药，比较两组治疗效果、临床症状评分、细胞因子水平及生活质量评分。结果 研究组总有效率为95.35%，高于对照组的81.40%（P＜0.05）；两组治疗后临床症状评分低于治疗前，且研究组低于对照组（P ＜0.05）；两组治疗后IL-4、LT、IFN-γ、IgE水平优于治疗前，且研究组优于对照组（P ＜0.05）；两组治疗后DLQI各维度评分低于治疗前，且研究组低于对照组（P ＜0.05）。结论 在奥洛他定治疗慢性荨麻疹期间联合应用孟鲁司特钠可有效缓解患者临床症状，调节免疫炎性因子水平，提高治疗效果，对促进患者病情康复、提高生活质量具有积极意义。

Effect of Montelukast Sodium Combined with Olatadine in the Treatment of Chronic Urticaria

Objective To explore the effect of montelukast sodium combined with olatadine in the treatment of chronic urticaria.Methods A total of 86 patients with chronic urticaria admitted to Hexi District Tianta Street Community Health Service Centerof Tianjin from November 2020 to November 2023 were selected and divided into control group and study group according todifferent treatment schemes, with 43 patients in each group. The control group was given olopatadine alone, and the study groupwas given montelukast sodium combined with olopatadine. The therapeutic effect, clinical symptom score, cytokine level andquality of life score were compared between the two groups. Results The total effective rate of the study group was 95.35%, whichwas higher than 81.40% of the control group (P <0.05). The clinical symptom scores of the two groups after treatment were lowerthan those before treatment, and those in the study group was better than those in the control group (P <0.05). The levels of IL-4, LT, IFN-γ and IgE in the two groups after treatment were better than those before treatment, and those in the study group werebetter than those in the control group (P <0.05). The scores of each dimension of DLQI in the two groups after treatment were lowerthan those before treatment, and those in the study group were lower than those in the control group (P <0.05). Conclusion Duringthe treatment of chronic urticaria with olopatadine, the combined application of montelukast sodium can effectively alleviate theclinical symptoms of patients, regulate the level of immune inflammatory factors, improve the therapeutic effect. It is of positivesignificance to promote the rehabilitation and improve the quality of life.