Exploring diagnostic and prognostic predictive values of microRNAs for acute myocardial infarction: A PRISMA-compliant systematic review and meta-analysis |
| |
| Authors: | Gien-Kuo Lee Yen-Ping Hsieh Shang-Wei Hsu Shou-Jen Lan |
| |
| Institution: | aDepartment of Healthcare Administration, Asia University, Taichung, Taiwan;bBenQ medical center, Emergency Department, Nanjing, China;cWei Gong Memorial Hospital, Emergency Department, Miaoli, Taiwan;dDepartment of Long Term Care, National Quemoy University, Taiwan;eDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. |
| |
| Abstract: | Objective:Previous investigations yielded inconsistent results for diagnostic and prognostic predictive values of MicroRNAs (miRNAs) for acute myocardial infarction (AMI).Methods and results:We systematically searched on PubMed and Web of Science for articles explored association of miRNAs and AMI published from January 1989 to March 2019. For diagnostic studies, a summary of sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR), which indicated the accuracy of microRNAs in the differentiation of AMI and no AMI, were calculated from the true positive (TP), true negative (TN), false positive (FP), and false negative (FN) of each study. In addition, the summary receive-operating characteristics (SROC) curve was constructed to summarize the TP and FP rates. For follow-up study, we computed hazard ratios (HRs) and 95% confidence intervals (CIs) for individual clinical outcomes. The meta-analysis showed a sensitivity 0.72 (95% CI: 0.61--0.81)] and specificity 0.88 (95% CI: 0.79--0.94)] of miR-1 for AMI. In addition, miR-133 showed a sensitivity 0.73 (95% CI: 0.55--0.85)] and specificity 0.88 (95% CI: 0.74--0.95)] for AMI. Moreover, the present study showed a sensitivity 0.83 (95% CI: 0.74--0.89)] and specificity 0.96 (95% CI: 0.82--0.99)] of miR-208 for AMI. A significant association was found between miR-208 and mortality after AMI (HR 1.09, 95% CI 1.01--1.18). It also indicated a sensitivity 0.84 (95% CI: 0.70--0.92)] and specificity 0.97 (95% CI: 0.87--0.99)] of miR-499 for AMI.Conclusions:Circulating miR-1, miR-133, miR-208, and miR-499 showed diagnostic values in AMI. |
| |
| Keywords: | acute myocardial infarction meta-analysis microRNAs |
|
|
