尖锐湿疣患者治疗前后血清hs—CRP和抵抗素检测的临床意义

目的探讨了尖锐湿疣患者治疗前后血清hs-CRP和抵抗素水平的变化及意义。方法采用酶联免疫（ELISA）法检测血清抵抗素含量，采用免疫比浊法对血清Hs—CRP进行测定；分别对62例尖锐湿疣患者进行了血清hs—CRP和抵抗素检测，并与35名正常健康人作比较。结果在治疗前尖锐湿疣患者hs-CRP和抵抗素水平均非常显著地高于正常人组（P〈0．01）。经3个月治疗后血清hs-CRP和抵抗素水平与正常人组比较无显著性差异（P〉0．05）。患者组治疗前后血清hs-CRP和抵抗素水平也有显著性差异（P〈0．01）。尖锐湿疣患者患者抵抗素浓度与Hs—CRP浓度呈正相关（r=0．73，P〈0．01）。结论检测尖锐湿疣患者血清hs-CRP和抵抗素水平的变化对疾病的治疗、预后观察有重要的临床价值。

Clinical significance of determination of changes hs-CRP and resistin levels after treatmentin patients with condyloma Acuminatum

Objective To explore the significance of changes of serum high sensitive C reactive protein (hs-CRP) and resistin levels after treatment in patients with condyloma acuminatum. Methods The concentrations of resistin was measured by enzyme-linked immunosorbent assay (ELISA) , and Hs-CRP was determined by rate nephelometry immunoassay and be measured both before and after treatment in 62 patients with condyloma acuminatum and 35 conrols. Results Before treatment, the serum hs-CRP and resistin levels in the patients were significantly higher than those in controls( P＜0.01). After treatment for 3 months, the levels were not significantly different from those in controls (P＞0.5).Serum hs-CRP and resistin lends in patients before the treatment were significantly higher than those after treatent (P＜0.01). There was positive correlation between the concentrations of resistin and hs-CRP in patients with condyloma acuminatum(r=0.73, P ＜ 0. 01 ). Conclusion The levels of serum hs-CRP and resistin increased significantly in patients with condyoma acuminatum especially in those advanced cases had important significance.