单核细胞增多型李氏忒菌诱导小鼠胸腺细胞凋亡 |
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摘 要: |
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关 键 词: | 单核细胞增多型李氏忒菌 胸腺细胞 细胞凋亡 动物疾病模型 小鼠 LM |
Listeria monocytogenes induces thymocyte apoptosis in mice] |
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Authors: | L Y Chen H M Jiang G J Wu |
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Institution: | Department of Microbiology, Xiangya School of Medicine, Central South University, Changsha 410078. |
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Abstract: | The murine thymocyte apoptosis induced by Listeria monocytogenes(LM) was detected with morphology, FCM, and DNA electrophoresis. The results were that LM elicited typical morphological changes of thymocyte apoptosis; the typical apoptosis peak was displayed with FCM, and typical "ladder pattern" with agarose gel electrophoresis. The apoptotic cells were found at 8 h after the mice had infected LM and reached climax at 48 h. The thymus weight significantly reduced at 16 h, and reached the lowest at 48 h after the mice had infected LM. The percentage of apoptotic cells was raised with the increasing of LM. These results suggest that LM induces thymocyte apoptosis in dose- and time-dependent manner. |
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