Intrasellar gangliocytomas associated with acromegaly |
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Authors: | Email author" target="_blank">Masamichi?KurosakiEmail author Wolfgang?Saeger Dieter?K?Lüdecke |
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Institution: | (1) Institute of Pathology, Marienkrankenhaus, Hamburg, Germany;(2) Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany;(3) Present address: Department of Neurosurgery, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Nishi-cho, Yonago, 683-8504 Tottori, Japan |
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Abstract: | The present study was designed to investigate the immunohistochemical characteristics of gangliocytomas associated with growth
hormone (GH)-secreting pituitary adenomas. In our surgical collection of 476 GH-secreting adenoma cases, we examined tumor
tissue from 6 patients (1.3%). All 6 patients were women, ranging from 29 to 52 years (mean, 40.3±9.5 SD) of age. Among 470
patients with GH-secreting adenomas without gangliocytoma, there were 255 female and 215 male patients. The preponderance
of female patients with gangliocytomas was striking. Histological examination of the resected specimens showed areas of ganglion
cells and adenomatous cells. Ganglion cell lesions were stained positively for synaptophysin (4 of 4; 100%) and neurofilament
(4 of 4; 100%) as well as GH-releasing hormone (5 of 6; 83.3%). Subtypes of GH cell adenomas included 4 cases of sparsely
granulated type and 2 cases of mixed GH and prolactin (PRL) cell adenomas. Based on these findings, we hypothesized that the
intrasellar gangliocytoma promoted the growth of the pituitary adenoma by chronic overstimulation from excess GH-releasing
hormone. |
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Keywords: | Acromegaly Gangliocytoma Pituitary adenoma Sella turcica |
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