IL-33 及其受体 ST2L 在变应性鼻炎中的研究进展

变应性鼻炎(AR)是特异性个体接触变应原后表现在鼻黏膜的一种非感染性炎性反应。 Th1/Th2 的免疫失衡在 AR 的发病机制中起重要作用。 白细胞介素（IL）-33 是新近发现的细胞因子， 是变应性疾病、自身免疫性疾病及多种炎性疾病中重要的调控因子。 IL-33 作为一种警报素， 主要由受损的组织、细胞分泌和释放， 尤其是受损的上皮细胞及内皮细胞。 IL-33 结合其受体 ST2L 可激活多种免疫细胞， 产生 Th2 型细胞因子， 促发及维持 Th2 极化， 加重 AR 的免疫炎症反应， 是研究和治疗 AR 的新靶向。 本文就 IL-33 及其受体 ST2L 的生物学功能及在 AR 中的研

Research advances in IL-33 and its receptor ST2L in allergic rhinitis

Allergic rhinitis (AR) is a specific individual after contact with allergens of the performance of a noninfectious inflammatory response in the nasal mucosa.Th1/Th2 immune imbalance may play an important role in the pathogenesis of AR.Interleukin 33 (IL-33), the novel cytokine of IL-1 family,is an important regulatory factor in allergic diseases, autoimmune diseases and various inflammatory diseases.IL-33 as an alarm, mainly by the secretion and release of tissues and cells damaged, especially impaired epithelial cells and endothelial cells.IL-33 binding to its receptor ST2L can activate a variety of immune cells to produce Th2 cytokines, precipitating and maintaining Th2 polarization, increased AR immune inflammation, which is the new targeted of AR in research and treatment. In this article,we will do a brief overview for the biological functions of IL-33 and its receptor ST2L and the research progress in the AR.