Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients |
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Authors: | Silvia Riondino Natalia Petrini Luciamaria Donato Concetta Torromeo Gaetano Tanzilli Fabio M Pulcinelli Francesco Barillà |
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Institution: | (1) Department of Experimental Medicine, “Sapienza” University of Rome, Viale Regina Elena 324, Rome, 00161, Italy;(2) Department of Cardiology, “Sapienza” University of Rome, Viale Regina Elena 324, Rome, 00161, Italy |
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Abstract: | Statin interference has been suggested among the mechanisms of reduction of the antiplatelet effect of clopidogrel. We thus
sought to assess the influence of rosuvastatin on clopidogrel antiplatelet action in high-risk (HR) cardiovascular patients.
To set the level of platelet inhibition by combined antithrombotic treatments we retrospectively studied two populations of
HR patients, one under aspirin alone, the other under aspirin plus rosuvastatin, before and after addition of clopidogrel.
The effects of rosuvastatin compared with atorvastatin were then prospectively investigated in patients who underwent percutaneous
coronary intervention (PCI), under clopidogrel and aspirin treatment. Light transmission platelet aggregation (LTA) was studied
in response to adenosine diphosphate (ADP) (5 μM) or arachidonic acid (0.5 mM). The inhibitory effect of clopidogrel in reducing
ADP-induced LTA was similar in the two HR groups of patients. No difference in ADP-induced platelet aggregation was observed
in the two PCI groups of patients with either atorvastatin or rosuvastatin. In conclusion, rosuvastatin does not interfere
with the antiplatelet effect of clopidogrel in patients with cardiovascular disease. |
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Keywords: | Rosuvastatin Clopidogrel Aspirin Platelet aggregation |
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