| 胸腺瘤组织中端粒酶活性检测的意义 |
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| 引用本文： | 杨胜生,曾志勇,程先进,庄聪文,张娟. 胸腺瘤组织中端粒酶活性检测的意义[J]. 现代肿瘤医学, 2010, 18(3) |
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| 作者姓名： | 杨胜生 曾志勇 程先进 庄聪文 张娟 |
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| 作者单位： | 南京军区福州总医院心胸外科,福建,福州,350025 |
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| 摘 要： | 目的:观察胸腺瘤组织及瘤旁组织端粒酶的活性,探讨其临床意义.方法:用改良的TRAP法检测18例侵袭性胸腺瘤、39例非侵袭性胸腺瘤和瘤旁组织以及20例正常胸腺组织端粒酶活性,用Tecan酶免分析仪连续测定其450-630nm的OD值.结果:18例侵袭性胸腺瘤及其瘤旁组织端粒酶阳性率及活性强度OD明显高于非侵袭性胸腺瘤.结论:端粒酶的检测有可能作为判别胸腺瘤良、恶性的新指标.
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| 关 键 词： | 胸腺瘤 端粒酶活性 聚合酶链反应 端粒重复扩增-酶联免疫吸附实验 |
Clinical significance of telamerase activity in thymoma |
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| YANG Sheng-sheng,ZENG Zhi-yong,CHENG Xian-jin,ZHUANG Cong-wen,ZHANG Juan. Clinical significance of telamerase activity in thymoma[J]. Journal of Modern Oncology, 2010, 18(3) |
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| Authors: | YANG Sheng-sheng ZENG Zhi-yong CHENG Xian-jin ZHUANG Cong-wen ZHANG Juan |
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| Affiliation: | YANG Sheng-sheng,ZENG Zhi-yong,CHENG Xian-jin,ZHUANG Cong-wen,ZHANG Juan Department of Cardiothoracic Surgery,Fuzhou General Hospital,Nanjing Comm,ing Region of PLA,Fuzhou 350025,China |
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| Abstract: | Objective:To observe the telomerase activity in thymoma and pericarcinomatous tissues,and its clinical significance.Methods:Telomerase activities were measured by telomere repeated amplification protocol (TRAP) PCR,ELISA in thymoma and pericarcinomatous tissues of 18 cases of invasive thymoma and 39 cases of non-invasive thymoma as well as in 20 cases of normal thymoma tissue.Results:The positive rate and density (optical density,OD) of telemerase activity in invasive thymoma and the pericarcinotous tissues... |
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| Keywords: | thymoma telomerase activity PCR TRAP-ELISA |
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