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胸腺瘤组织中端粒酶活性检测的意义
引用本文:杨胜生,曾志勇,程先进,庄聪文,张娟. 胸腺瘤组织中端粒酶活性检测的意义[J]. 现代肿瘤医学, 2010, 18(3)
作者姓名:杨胜生  曾志勇  程先进  庄聪文  张娟
作者单位:南京军区福州总医院心胸外科,福建,福州,350025
摘    要:目的:观察胸腺瘤组织及瘤旁组织端粒酶的活性,探讨其临床意义.方法:用改良的TRAP法检测18例侵袭性胸腺瘤、39例非侵袭性胸腺瘤和瘤旁组织以及20例正常胸腺组织端粒酶活性,用Tecan酶免分析仪连续测定其450-630nm的OD值.结果:18例侵袭性胸腺瘤及其瘤旁组织端粒酶阳性率及活性强度OD明显高于非侵袭性胸腺瘤.结论:端粒酶的检测有可能作为判别胸腺瘤良、恶性的新指标.

关 键 词:胸腺瘤  端粒酶活性  聚合酶链反应  端粒重复扩增-酶联免疫吸附实验

Clinical significance of telamerase activity in thymoma
YANG Sheng-sheng,ZENG Zhi-yong,CHENG Xian-jin,ZHUANG Cong-wen,ZHANG Juan. Clinical significance of telamerase activity in thymoma[J]. Journal of Modern Oncology, 2010, 18(3)
Authors:YANG Sheng-sheng  ZENG Zhi-yong  CHENG Xian-jin  ZHUANG Cong-wen  ZHANG Juan
Affiliation:YANG Sheng-sheng,ZENG Zhi-yong,CHENG Xian-jin,ZHUANG Cong-wen,ZHANG Juan Department of Cardiothoracic Surgery,Fuzhou General Hospital,Nanjing Comm,ing Region of PLA,Fuzhou 350025,China
Abstract:Objective:To observe the telomerase activity in thymoma and pericarcinomatous tissues,and its clinical significance.Methods:Telomerase activities were measured by telomere repeated amplification protocol (TRAP) PCR,ELISA in thymoma and pericarcinomatous tissues of 18 cases of invasive thymoma and 39 cases of non-invasive thymoma as well as in 20 cases of normal thymoma tissue.Results:The positive rate and density (optical density,OD) of telemerase activity in invasive thymoma and the pericarcinotous tissues...
Keywords:thymoma  telomerase activity  PCR  TRAP-ELISA  
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