| 布洛芬缓释胶囊含量测定方法改进 |
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| 引用本文： | 陈德俊,郑静.布洛芬缓释胶囊含量测定方法改进[J].齐鲁药事,2007,26(3):163-164. |
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| 作者姓名： | 陈德俊 郑静 |
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| 作者单位： | 山东省药品检验所,山东,济南,250012 |
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| 摘 要： | 目的改进布洛芬缓释胶囊含量测定方法。方法采用Agilent C18色谱柱(4.6mm×150mm,5μm),以甲醇-0.01mol.L-1磷酸二氢钾-磷酸(700∶300∶0.1)为流动相;检测波长为263nm。结果布洛芬在50~1000μg.mL-1时,与峰面积比值呈良好线性关系,r=0.9999。结论该法简便、准确,容易操作,可用于该品种的含量测定。
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| 关 键 词： | 布洛芬缓释胶囊 高效液相色谱法 含量测定 |
| 文章编号： | 1672-7738(2007)03-0163-02 |
Improvement of determination method of Ibuprofen Sustained Release Capsules |
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| CHEN De-jun,ZHENG Jing.Improvement of determination method of Ibuprofen Sustained Release Capsules[J].qilu pharmaceutical affairs,2007,26(3):163-164. |
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| Authors: | CHEN De-jun ZHENG Jing |
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| Abstract: | OBJECTIVE To improve the method of content determination of Ibuprofen Sustained Release Capsules.METHODS An Agilent C18 column(4.6mm×150mm,5μm)was used.The mobile phase consisted of methanol-0.01mol·L-1 potassium dihydrogen phosphate solution-phosphoric acid(700∶300∶0.1),the UV detection wavelength was 263nm.RESULTS There was a good linear relationship in the range of 50～1000μg·mL-1(r=0.9999).CONCLUSION The method was specific,accurate and convenient,and can be used for content determination of Ibuprofen Sustained Release Capsules. |
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| Keywords: | Ibuprofen Sustained Release Capsules HPLC determination |
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