In vitro activity of MDL 62,879 against gram-positive bacteria andBacteroides species |
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| Authors: | A. Bartoloni A. Mantella B. P. Goldstein M. Denaro P. Nicoletti F. Paradisi |
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| Affiliation: | (1) Clinica di Malattie Infettive, Università di Firenze, Nuovo Ospedale S. Giovanni di Dio, via di Torregalli 3, 50143 Firenze, Italy;(2) Lepetit Research Center, Marion Merrel Dow Research Institute, Gerenzano (VA), Italy;(3) Azienda Ospedaliera di Careggi, Laboratorio di Microbiologia e Virologia, Firenze, Italy |
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| Abstract: | The new thiazolyl peptide antibiotic MDL 62,879 (GE2270 A) showed excellent in vitro activity in testing against staphylococci and streptococci, with MIC90s ranging from 0.23 to 0.9 mg/l. It was very active againstClostridium difficile andPropionibacterium acnes (MIC90 0.06 mg/l in each case) and had variable activity againstBacteroides spp. MDL 62,879 had exceptionally good activity againstEnterococcus faecalis, including against a collection of high-level aminoglycoside-resistant isolates where it had an MIC90 of 0.047. The antibiotic was bacteriostatic for enterococcal isolates but bactericidal for a methicillin-resistant isolate ofStaphylococcus aureus. |
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