阻塞性睡眠呼吸暂停综合征与高血压的相关性

目的 探讨阻塞性睡眠呼吸暂停综合征(OSAS)与高血压的相关性.方法 按照睡眠资料和24 h血压资料,分为单纯高血压组与合并OSAS高血压组,口服药物治疗4周,比较治疗前后血压变化,OSAS组降压效果差的患者同时接受持续气道正压(CPAP)治疗,观察血压控制情况.结果 30例单纯高血压患者,常规药物降压治疗4周后,血压较治疗前明显下降(P<0.05);OSAS组药物治疗前后无明显变化,再同时用CPAP治疗4周后晨起血压明显下降.结论 合并有OSAS的高血压患者多为难治性,单纯降压药物治疗效果欠佳,需要同时应用CPAP治疗.

Relationship between obstructive sleep apnea syndrome and hypertension

Objective To investigate the relationship between obstructive sleep apnea syndrome(OSAS)and hypertension.Methods We used 24-hour ABPM and polysomnography(PSG) simultaneously to classify the hypertensive patients and the hypertensive patients with OSAS.Both groups used medicine for 4 weeks.The measures of their blood pressures were compared before and after the treatment.The OSAS group with poor results in terms of pressure control were given CPAP for 4 weeks,and the changes of blood pressure were observed.Results After 4 weeks antihypertensive treatment,24 h BP decreased in the 30 hypertensive patients(P<0.05);and decreased mildly in the 25 hypertensive patients with OSAS.After using CPAP for 4 weeks,the blood pressure in the morning after night sleep was significantly decreased as compared with that before the treatment.Conclusion Most hypertensive patients with OSAS are refractory to antihypertensive drug treatment,and CPAP treatment should be considered in these patients.