Effects of experimental acute tryptophan depletion on acoustic startle response in females |
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Authors: | Christine Norra Stefanie Becker Sabine C Herpertz Hanns Jürgen Kunert |
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Institution: | (1) Department of Psychiatry and Psychotherapy, University Hospital RWTH, Aachen, Germany;(2) Department of Psychiatry and Psychotherapy, University Hospital, Kiel, Germany;(3) Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany;(4) Division of Clinical Neurosciences, Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Goettingen, Germany |
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Abstract: | Previous studies suggest an important role for serotonergic (5-HT) modulation of the acoustic startle reflex (ASR) and prepulse
inhibition (PPI). Acute challenge of brain serotonin by means of tryptophan depletion test (TDT) represents an established
human challenge tool for temporary reduction of tryptophan (−TRP) levels and central nervous serotonin. Under these experimental
conditions, PPI was found attenuated in males, but greater biochemical effects of TDT in the central nervous system of females
are known. Therefore, in order to explore influence of 5-HT on various standard startle parameters in females, 16 young healthy
females participated in a double-blind, cross-over TDT study. Acoustic stimuli were presented in 15 pulse-alone trials (100 dB,
40 ms) randomly followed by 25 pulse-alone or prepulse (70 dB, 30 ms; 120 ms interval) trials alongside electromyographic
eyeblink recordings and mood state assessments. During 81% depletion of free plasma TRP, mean ASR magnitudes were significantly
reduced compared to control (+TRP) condition while there were no differences in habituation or PPI nor did startle parameters
correlate with mood states. Changes of plasma TRP and mood states correlated in tendency negatively in (−TRP) for depression
and positively in (+TRP) for fatigue. In conclusion, this first study of startle parameters after TDT in a homogenous female
population demonstrates that depletion of brain 5-HT in women only influences ASR. |
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Keywords: | acoustic startle response mood states prepulse inhibition serotonin tryptophan depletion |
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